Document Detail

Farm residence and exposures and the risk of allergic diseases in New Zealand children.
MedLine Citation:
PMID:  12464046     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Studies in Europe have reported a reduced prevalence of allergy in farmers' children. We aimed to determine if there is a similar reduction in allergy among New Zealand farm children. METHODS: Two hundred and ninety-three children participated (60%) aged 7-10 years, from selected schools in small towns and the surrounding rural area. Skin prick tests (SPT) to eight common allergens were performed. Parents completed questionnaires about allergic and infectious diseases, place of residence, exposure to animals, and diet, and they provided dust from the living-room floor. Endotoxin was measured using an Limulus amoebocyte lysate (LAL) assay and Der p 1 using enzyme-linked immunoassay (ELISA). RESULTS: Current farm abode was found to increase the risk of having symptoms associated with allergy, but not SPT positivity. Independent inverse associations were found for early-life exposures: at least weekly consumption of yoghurt with hayfever (odds ratio (OR) = 0.3, 95% confidence intervals (CI) 0.1-0.7) and allergic rhinitis (OR = 0.3, 95% CI 0.2-0.7); any unpasteurized milk consumption with atopic eczema/dermatitis syndrome (AEDS) (OR = 0.2, 95% CI 0.1-0.8); cats inside or outside with hayfever (OR = 0.4, 95% CI 0.1-1.0) and AEDS (OR = 0.4, 95% CI 0.2-0.8); dogs inside or outside with asthma (OR = 0.4, 95% CI 0.2-0.8); and pigs with SPT positivity (OR = 0.2, 95% CI 0.1-0.9). CONCLUSIONS: Despite finding a protective effect of early-life animal exposures, we found a greater prevalence of allergic disease on farms.
K Wickens; J M Lane; P Fitzharris; R Siebers; G Riley; J Douwes; T Smith; J Crane
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Allergy     Volume:  57     ISSN:  0105-4538     ISO Abbreviation:  Allergy     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2002-12-04     Completed Date:  2003-04-16     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7804028     Medline TA:  Allergy     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  1171-9     Citation Subset:  IM    
Wellington Asthma Research Group, University of Otago, Wellington South, New Zealand.
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MeSH Terms
Air Pollutants / adverse effects,  analysis
Allergens / adverse effects,  analysis
Animals, Domestic / immunology*
Antigens, Dermatophagoides / adverse effects,  analysis
Child Welfare
Endotoxins / adverse effects,  analysis
Environmental Exposure / adverse effects*,  analysis
Family Health
Multivariate Analysis
New Zealand / epidemiology
Respiratory Hypersensitivity / epidemiology*,  etiology*
Risk Factors
Rural Health
School Health Services
Skin Tests
Statistics as Topic
Reg. No./Substance:
0/Air Pollutants; 0/Allergens; 0/Antigens, Dermatophagoides; 0/Endotoxins; EC 3.4.22.-/Dermatophagoides pteronyssinus antigen p 1
Comment In:
Allergy. 2002 Dec;57(12):1094-6   [PMID:  12464036 ]

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