Document Detail

Fanconi's anemia: the preanemic phase.
MedLine Citation:
PMID:  94509     Owner:  NLM     Status:  MEDLINE    
Anticipation of Franconi's anemia prior to the development of overt marrow aplasia may prevent some morbidity and mortality from infectious and hemorrhagic complications. A presumptive diagnosis was made in a firstborn child and radial anomalies, small size, elevated fetal hemoglobin, intermittent excessive chromosome breakage and elevated T-antigen expression in fibroblasts infected with Simian virus 40. Serial studies may help identify infants and young children at risk to develop this type of constitutional marrow hypoplasia.
S McIntosh; W R Breg; A S Lubiniecki
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of pediatric hematology/oncology     Volume:  1     ISSN:  0192-8562     ISO Abbreviation:  Am J Pediatr Hematol Oncol     Publication Date:  1979  
Date Detail:
Created Date:  1980-06-25     Completed Date:  1980-06-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7908071     Medline TA:  Am J Pediatr Hematol Oncol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  107-10     Citation Subset:  IM    
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MeSH Terms
Anemia, Aplastic / diagnosis*
Antigens, Viral / analysis
Blood Cell Count
Bone Marrow / pathology
Child, Preschool
Chromosome Aberrations
Fanconi Anemia / blood,  diagnosis*,  genetics
Fetal Hemoglobin / analysis
Infant, Newborn
Infant, Newborn, Diseases / genetics*
Simian virus 40 / immunology
Reg. No./Substance:
0/Antigens, Viral; 9034-63-3/Fetal Hemoglobin

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