Document Detail

Fanconi's anemia lymphocytes: effect of caffeine, adenosine and niacinamide during G2 prophase.
MedLine Citation:
PMID:  2966295     Owner:  NLM     Status:  MEDLINE    
In this investigation peripheral blood lymphocytes from 3 Fanconi's anemia (FA) patients, 2 FA heterozygotes and 4 normal subjects were treated with caffeine and/or adenosine, and/or niacinamide during G2 prophase. Caffeine dramatically increased breakage levels in homozygote and heterozygote cells. Niacinamide and adenosine decreased the amount of chromosomal aberrations detected in FA homozygote and heterozygote lymphocytes treated and untreated with caffeine during G2 prophase. Caffeine sensitivity of heterozygote lymphocytes is proposed as a new clinical test to explore heterozygosis in individuals of FA families.
J Pincheira; M Bravo; J F López-Sáez
Related Documents :
21937535 - Role of peltigera rufescens (weis) humb. (a lichen) on imazalil-induced genotoxicity: a...
15979995 - Presence of membrane and soluble forms of fas ligand and of matrilysin (mmp-7) activity...
9634525 - Fine localization of the nijmegen breakage syndrome gene to 8q21: evidence for a common...
17471025 - New roads to fa/brca pathway: h2ax.
11161215 - Recolonizing carnivores and naïve prey: conservation lessons from pleistocene extinctio...
24899465 - Ftx is dispensable for imprinted x-chromosome inactivation in preimplantation mouse emb...
Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Mutation research     Volume:  199     ISSN:  0027-5107     ISO Abbreviation:  Mutat. Res.     Publication Date:  1988 May 
Date Detail:
Created Date:  1988-06-07     Completed Date:  1988-06-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0400763     Medline TA:  Mutat Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  159-65     Citation Subset:  IM    
Depto. de Biología Celular y Genética, Facultad de Medicina, Universidad de Chile, Santiago.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adenosine / pharmacology*
Anemia, Aplastic / genetics*
Caffeine / pharmacology*
Chromosome Aberrations*
DNA Repair / drug effects*
Fanconi Anemia / genetics*
NAD / physiology
Niacinamide / pharmacology*
Reg. No./Substance:
53-84-9/NAD; 58-08-2/Caffeine; 58-61-7/Adenosine; 98-92-0/Niacinamide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Damage-resistant DNA synthesis in eukaryotes.
Next Document:  Effect of the homokaryotic state of the uvs-2 allele in Neurospora crassa on formaldehyde-induced ki...