Document Detail


Fanconi's anemia lymphocytes: effect of caffeine, adenosine and niacinamide during G2 prophase.
MedLine Citation:
PMID:  2966295     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this investigation peripheral blood lymphocytes from 3 Fanconi's anemia (FA) patients, 2 FA heterozygotes and 4 normal subjects were treated with caffeine and/or adenosine, and/or niacinamide during G2 prophase. Caffeine dramatically increased breakage levels in homozygote and heterozygote cells. Niacinamide and adenosine decreased the amount of chromosomal aberrations detected in FA homozygote and heterozygote lymphocytes treated and untreated with caffeine during G2 prophase. Caffeine sensitivity of heterozygote lymphocytes is proposed as a new clinical test to explore heterozygosis in individuals of FA families.
Authors:
J Pincheira; M Bravo; J F López-Sáez
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Mutation research     Volume:  199     ISSN:  0027-5107     ISO Abbreviation:  Mutat. Res.     Publication Date:  1988 May 
Date Detail:
Created Date:  1988-06-07     Completed Date:  1988-06-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0400763     Medline TA:  Mutat Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  159-65     Citation Subset:  IM    
Affiliation:
Depto. de Biología Celular y Genética, Facultad de Medicina, Universidad de Chile, Santiago.
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MeSH Terms
Descriptor/Qualifier:
Adenosine / pharmacology*
Anemia, Aplastic / genetics*
Caffeine / pharmacology*
Chromosome Aberrations*
DNA Repair / drug effects*
Fanconi Anemia / genetics*
Humans
Interphase*
Lymphocytes
NAD / physiology
Niacinamide / pharmacology*
Chemical
Reg. No./Substance:
53-84-9/NAD; 58-08-2/Caffeine; 58-61-7/Adenosine; 98-92-0/Niacinamide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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