| Fanconi's Syndrome Associated with Prolonged Adefovir Dipivoxil Therapy in a Hepatitis B Virus Patient. | |
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MedLine Citation:
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PMID: 20981219 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Adefovir dipivoxil (ADV) is commonly used as an antiviral agent in the treatment of chronic hepatitis B or human immunodeficiency virus infection. Nephrotoxicity has been shown to occur at daily dosages of 60-120 mg. Fanconi's syndrome is a generalized dysfunction of the renal proximal tubular cells, which is usually accompanied by complications. Here we report a case of Fanconi's syndrome in a chronic hepatitis B patient who had been treated with a prolonged regimen of ADV at 10 mg/day. A 47-year-old man complained of severe back and chest-wall pain. He had chronic hepatitis B and had been treated with ADV at a daily dose of 10 mg for 38 months. He was hospitalized because of severe bone pain, and laboratory and radiologic findings suggested a diagnosis of Fanconi's syndrome with osteomalacia. After discontinuation of the ADV, he recovered and was discharged from hospital. His laboratory findings had normalized within 2 weeks. This case indicates that Fanconi's syndrome can be acquired by a chronic hepatitis B patient taking ADV at a conventional dosage of 10 mg/day. Therefore, patients treated with long-term ADV should be checked regularly for the occurrence of ADV-induced Fanconi's syndrome. |
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Authors:
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Young Kul Jung; Jong Eun Yeon; Jong Hwan Choi; Chung Ho Kim; Eun Suk Jung; Ji Hoon Kim; Jong Jae Park; Jae Seon Kim; Young-Tae Bak; Kwan Soo Byun |
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Publication Detail:
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Type: Journal Article Date: 2010-09-24 |
Journal Detail:
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Title: Gut and liver Volume: 4 ISSN: 1976-2283 ISO Abbreviation: Gut Liver Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-10-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101316452 Medline TA: Gut Liver Country: Korea (South) |
Other Details:
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Languages: eng Pagination: 389-93 Citation Subset: - |
Affiliation:
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Department of Internal Medicine, Gachon University of Medicine and Science Gil Medical Center, Incheon, Korea. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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