Document Detail

Fanconi syndrome associated with cephalothin and gentamicin therapy.
MedLine Citation:
PMID:  343914     Owner:  NLM     Status:  MEDLINE    
A case is reported of Fanconi syndrome and nonliquric renal failure, following a brief course of cephalothin and gentamicin, in a patient with diffuse histiocytic lymphoma. These drugs, especially when used in combination, have been associated with nephrotoxicity manifested as acute tubular necrosis and altered proximal tubular function, but biochemical evidence for generalized proximal tubular dysfunction has not been accurately defined. Thus far, only two other antibiotics, degraded tetracycline and streptozotocin, have been implicated in producing an acquired Fanconi syndrome.
J H Schwartz; P Schein
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Cancer     Volume:  41     ISSN:  0008-543X     ISO Abbreviation:  Cancer     Publication Date:  1978 Feb 
Date Detail:
Created Date:  1978-05-17     Completed Date:  1978-05-17     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0374236     Medline TA:  Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  769-72     Citation Subset:  AIM; IM    
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MeSH Terms
Bacterial Infections / complications,  drug therapy
Cephalothin / adverse effects*
Drug Synergism
Drug Therapy, Combination
Fanconi Syndrome / chemically induced*,  complications
Gentamicins / adverse effects*
Lymphoma, Large B-Cell, Diffuse / complications
Middle Aged
Reg. No./Substance:
0/Gentamicins; 153-61-7/Cephalothin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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