Document Detail

Fanconi anaemia and the repair of Watson and Crick DNA crosslinks.
MedLine Citation:
PMID:  23325218     Owner:  NLM     Status:  MEDLINE    
The function of Fanconi anaemia proteins is to maintain genomic stability. Their main role is in the repair of DNA interstrand crosslinks, which, by covalently binding the Watson and the Crick strands of DNA, impede replication and transcription. Inappropriate repair of interstrand crosslinks causes genomic instability, leading to cancer; conversely, the toxicity of crosslinking agents makes them a powerful chemotherapeutic. Fanconi anaemia proteins can promote stem-cell function, prevent tumorigenesis, stabilize replication forks and inhibit inaccurate repair. Recent advances have identified endogenous aldehydes as possible culprits of DNA damage that may induce the phenotypes seen in patients with Fanconi anaemia.
Molly C Kottemann; Agata Smogorzewska
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Nature     Volume:  493     ISSN:  1476-4687     ISO Abbreviation:  Nature     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-17     Completed Date:  2013-03-04     Revised Date:  2014-01-24    
Medline Journal Info:
Nlm Unique ID:  0410462     Medline TA:  Nature     Country:  England    
Other Details:
Languages:  eng     Pagination:  356-63     Citation Subset:  IM    
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MeSH Terms
Cell Transformation, Neoplastic
DNA / chemistry,  genetics,  metabolism*
DNA Repair*
Ethanol / metabolism
Fanconi Anemia / genetics*,  metabolism*,  pathology
Fanconi Anemia Complementation Group Proteins / metabolism*
Stem Cells / metabolism
Grant Support
Reg. No./Substance:
0/Fanconi Anemia Complementation Group Proteins; 3K9958V90M/Ethanol; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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