| Fanconi anaemia and the repair of Watson and Crick DNA crosslinks. | |
| | |
MedLine Citation:
|
PMID: 23325218 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The function of Fanconi anaemia proteins is to maintain genomic stability. Their main role is in the repair of DNA interstrand crosslinks, which, by covalently binding the Watson and the Crick strands of DNA, impede replication and transcription. Inappropriate repair of interstrand crosslinks causes genomic instability, leading to cancer; conversely, the toxicity of crosslinking agents makes them a powerful chemotherapeutic. Fanconi anaemia proteins can promote stem-cell function, prevent tumorigenesis, stabilize replication forks and inhibit inaccurate repair. Recent advances have identified endogenous aldehydes as possible culprits of DNA damage that may induce the phenotypes seen in patients with Fanconi anaemia. |
| | |
Authors:
|
Molly C Kottemann; Agata Smogorzewska |
Related Documents
:
|
8332468 - Elimination of band compression in sequencing gels by the use of n4-methyl-2'-deoxycyti... 6421608 - Intracellular localization and metabolism of dna polymerase alpha in human cells visual... 7019918 - Intracellular localization of dna polymerase alpha. 3763398 - Dna replication and uv-induced dna repair synthesis in human fibroblasts are much less ... 1354898 - Evaluation in a battery of in vivo assays of four in vitro genotoxins proved to be nonc... 8167238 - Transgenic cattle resulting from biopsied embryos: expression of c-ski in a transgenic ... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
|
Title: Nature Volume: 493 ISSN: 1476-4687 ISO Abbreviation: Nature Publication Date: 2013 Jan |
Date Detail:
|
Created Date: 2013-01-17 Completed Date: 2013-03-04 Revised Date: 2013-04-22 |
Medline Journal Info:
|
Nlm Unique ID: 0410462 Medline TA: Nature Country: England |
Other Details:
|
Languages: eng Pagination: 356-63 Citation Subset: IM |
Affiliation:
|
Laboratory of Genome Maintenance, The Rockefeller University, New York 10065, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Cell Transformation, Neoplastic DNA / chemistry, genetics, metabolism* DNA Repair* Ethanol / metabolism Fanconi Anemia / genetics*, metabolism*, pathology Fanconi Anemia Complementation Group Proteins / metabolism* Humans Stem Cells / metabolism |
| Grant Support | |
ID/Acronym/Agency:
|
8 UL1 TR000043/TR/NCATS NIH HHS; UL1 TR000043/TR/NCATS NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Fanconi Anemia Complementation Group Proteins; 64-17-5/Ethanol; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Metabolism of inflammation limited by AMPK and pseudo-starvation.
Next Document: Ultrahard nanotwinned cubic boron nitride.