Document Detail


Family studies in fetal phenytoin exposure.
MedLine Citation:
PMID:  3397793     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sixty-two families with fetal diphenylhydantoin exposure were studied during two or more pregnancies. In 15 of these families at least one of the exposed children had some of the physical effects of DPH exposure ("affected" families); in the remaining 47 families no exposed child was affected ("unaffected" families). Review of 62 family histories and pedigrees was not helpful in differentiating these two groups for counseling purposes. However, mothers who had one affected child appeared to be at much higher risk for having subsequent affected children (9 of 10) if phenytoin use was continued through future pregnancies than were mothers whose first-born child was unaffected despite being exposed to phenytoin during the pregnancy (5 of 52 among all families, or 1 of 48 when only children exposed throughout the entire pregnancy were included). The difference between families with the first exposed child affected and first exposed child unaffected was highly statistically significant (p less than 0.0001). School and learning problems and developmental or mental retardation were present in both groups, and significantly more frequently in affected families. Physical and growth abnormalities were noted in both affected and unaffected family groups, also at a significantly higher rate in affected families.
Authors:
D C Van Dyke; S E Hodge; F Heide; L R Hill
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  113     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  1988 Aug 
Date Detail:
Created Date:  1988-09-08     Completed Date:  1988-09-08     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  301-6     Citation Subset:  AIM; IM    
Affiliation:
Department of Pediatrics, University of Iowa College of Medicine, Iowa City.
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MeSH Terms
Descriptor/Qualifier:
Abnormalities, Drug-Induced / genetics
Child
Embryonic and Fetal Development / drug effects
Family
Fathers
Female
Humans
Male
Medical History Taking
Phenytoin / administration & dosage,  adverse effects*
Pregnancy
Prenatal Exposure Delayed Effects*
Risk Factors
Syndrome
Grant Support
ID/Acronym/Agency:
DK-01145/DK/NIDDK NIH HHS; DK-31813/DK/NIDDK NIH HHS; S07RR5471/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
57-41-0/Phenytoin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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