Document Detail


Family score as an indicator of genetic risk of primary open-angle glaucoma.
MedLine Citation:
PMID:  12470149     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To assess the genetic risk of open-angle glaucoma (OAG) in individuals by calculating a family score (FS), which summarizes the information of all relatives including their disease status, age, sex, and degree of kinship and to examine the genetic contribution to OAG with and without an increased intraocular pressure. METHODS: Case and control probands, derived from the Rotterdam Study, underwent the same ophthalmologic examination as their relatives. The FS of each proband was the sum of the differences between observed and expected values of OAG for all relatives. The FSs were compared between case and control probands using logistic regression analysis, adjusted for intraocular pressure. RESULTS: Of 37 case probands, 44 (half-) siblings and 86 children were available, and of 83 control probands there were 97 (half-) siblings and 155 children. Family scores ranged from -0.44 to 7.08 in case probands and from -0.98 to 2.46 in control probands. One unit increase in FS was significantly associated with a higher risk of OAG (odds ratio, 1.59; 95% confidence interval, 1.14-2.23). Adjustments for intraocular pressure did not change the odds ratio. CONCLUSIONS: These data show that the FS strongly predicts OAG, independent of the intraocular pressure. Therefore, the FS is useful to identify individuals with a high genetic risk.
Authors:
Caroline A A Hulsman; Jeanine J Houwing-Duistermaat; Cornelia M Van Duijn; Roger Wolfs; Petra H Borger; Albert Hofman; Paulus T V M De Jong
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of ophthalmology     Volume:  120     ISSN:  0003-9950     ISO Abbreviation:  Arch. Ophthalmol.     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2002-12-09     Completed Date:  2002-12-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7706534     Medline TA:  Arch Ophthalmol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1726-31     Citation Subset:  AIM; IM    
Affiliation:
The Netherlands Ophthalmic Research Institute, KNAW, Meibergdreef 47, 1105 BA Amsterdam, the Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Family Health*
Female
Glaucoma, Open-Angle / epidemiology*,  genetics*
Humans
Intraocular Pressure
Logistic Models
Male
Middle Aged
Models, Genetic
Netherlands / epidemiology
Nuclear Family
Prevalence
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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