Document Detail


Family history of premature coronary heart disease, child cardio-metabolic risk factors and left ventricular mass.
MedLine Citation:
PMID:  24107484     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
In a prospective cohort of 181 individuals followed up since childhood - when aged 9, 12 and 15 years - patients with a family history of premature coronary heart disease (n=18) had higher left ventricular mass index in adulthood - at mean age of 31 years - compared with those without (mean±standard error 39.1±1.9 versus 34.6±0.7 g/m2.7, p=0.04). The correlation between adult left ventricular mass index and child triglycerides (r=0.66, p=0.04 versus r=-0.03, p=0.75; pdiff=0.02) and diastolic blood pressure (r=0.65, p=0.02 versus r=0.16, p=0.07; pdiff=0.05) was stronger among those with a family history of coronary heart disease than in those without. Although preliminary, these data suggest that the higher left ventricular mass index among adults with a family history might be explained by their increased susceptibility to child cardio-metabolic risk factors.
Authors:
Costan G Magnussen; Terence Dwyer; Alison Venn
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-10-10
Journal Detail:
Title:  Cardiology in the young     Volume:  -     ISSN:  1467-1107     ISO Abbreviation:  Cardiol Young     Publication Date:  2013 Oct 
Date Detail:
Created Date:  2013-10-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9200019     Medline TA:  Cardiol Young     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1-3     Citation Subset:  -    
Affiliation:
1 Menzies Research Institute Tasmania, University of Tasmania, Hobart, Australia.
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