Document Detail

Family history in assessing the risk for progression of mitral valve prolapse. Report of a kindred.
MedLine Citation:
PMID:  7246493     Owner:  NLM     Status:  MEDLINE    
Mitral valve prolapse (MVP) consists of prolapse or billowing of the mitral leaflet(s) into the left atrium during ventricular systole associated with a mid-to-late systolic click and/or a late systolic murmur. Thoracic skeletal abnormalities, progressive mitral regurgitation, ventricular arrhythmia, and sudden death have been associated with an autosomal dominant "MVP syndrome." The discovery of MVP in an asymptomatic 8-year-old boy led to a family investigation with subsequent delineation of age-related, progressive, mitral valve disease through four generations of the kindred. Although generally considered a benign syndrome, obtaining a full family history is important in assessing the risk for progression of mitral valve disease in affected family members.
M J Cooper; E G Abinader
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  American journal of diseases of children (1960)     Volume:  135     ISSN:  0002-922X     ISO Abbreviation:  Am. J. Dis. Child.     Publication Date:  1981 Jul 
Date Detail:
Created Date:  1981-08-27     Completed Date:  1981-08-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370471     Medline TA:  Am J Dis Child     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  647-9     Citation Subset:  AIM; IM    
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MeSH Terms
Age Factors
Death, Sudden / etiology
Genes, Dominant
Mitral Valve Prolapse / genetics*
Thorax / abnormalities

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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