Document Detail


Family history of hypertension and red cell cation transport in high school students.
MedLine Citation:
PMID:  6681034     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
High school students who had at least one parent with hypertension (n = 22) were compared to schoolmates of the same age with a negative family history of hypertension in the parents (n = 21). We investigated in both groups the maximal rate of the ouabain-sensitive Na pump and the Na-K cotransport in nystatin-loaded cells and the Lii-Nao countertransport in lithium-loaded cells. The two groups were significantly different only in the sum of net Na transport mediated by the Na-K pump and Na-K cotransport. The mean diastolic blood pressure in the positive family history group was significantly higher. With control for blood pressure the difference in the maximal rate of Na transport was no longer significant; it remains uncertain if control for blood pressure represents "over-adjustment'. The finding of a higher maximal rate of Na transport in these adolescents who are at increased risk of future hypertension, yet currently well within the normal range, suggests that abnormal sodium metabolism may be a useful marker and appears early in the pathogenesis of this disease.
Authors:
R Cooper; K Miller; M Trevisan; C Sempos; E Larbi; H Ueshima; D Le Grady; D Ostrow; J Stamler; A Spalvins
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of hypertension     Volume:  1     ISSN:  0263-6352     ISO Abbreviation:  J. Hypertens.     Publication Date:  1983 Aug 
Date Detail:
Created Date:  1985-04-26     Completed Date:  1985-04-26     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  145-52     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Biological Transport
Blood Pressure
Erythrocytes / metabolism*
Female
Humans
Hypertension / blood*,  genetics
Lithium / blood
Male
Potassium / blood*
Sex Factors
Sodium / blood*
Grant Support
ID/Acronym/Agency:
GM-25686/GM/NIGMS NIH HHS; HL-25064/HL/NHLBI NIH HHS; HL-26124-02/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
7439-93-2/Lithium; 7440-09-7/Potassium; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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