Document Detail

Family history does not predict angiographic localization or severity of coronary artery disease.
MedLine Citation:
PMID:  22341867     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Family history of MI is an established risk factor for coronary artery disease and subclinical atherosclerosis. Maternal MI and maternal stroke are more common in females than males presenting with acute coronary syndromes (ACS), suggesting sex-specific heritability, but the effects of family history on location and extent of coronary artery disease are unknown.
METHODS: In a prospective, population-based study (Oxford Vascular Study) of all patients with ACS, family history data for stroke and MI were analysed by sex of proband and affected first degree relatives (FDRs), and coronary angiograms were reviewed, where available.
RESULTS: Of 835 probands with one or more ACS, 623 (420 males) had incident events and complete family history data. 351 patients with incident events (56.3%; 266 males) underwent coronary angiography. Neither angiographic disease localization nor severity were associated with sex-of-parent/sex-of-offspring in men or women.
CONCLUSIONS: Sex-specific family history data do not predict angiographic localization of coronary disease in patients presenting with ACS. Maternal stroke and maternal MI probably affect ACS in females by a mechanism unrelated to atherosclerosis or coronary anatomy. However, family history data may still be useful in risk prediction and prognosis of ACS.
Amitava Banerjee; Chris C S Lim; Louise E Silver; Carl Heneghan; Sarah J V Welch; Ziyah Mehta; Adrian P Banning; Peter M Rothwell
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-01-30
Journal Detail:
Title:  Atherosclerosis     Volume:  221     ISSN:  1879-1484     ISO Abbreviation:  Atherosclerosis     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-03-26     Completed Date:  2012-07-26     Revised Date:  2014-02-24    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  451-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.
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MeSH Terms
Aged, 80 and over
Analysis of Variance
Chi-Square Distribution
Coronary Angiography
Coronary Artery Disease / epidemiology,  genetics*,  radiography
England / epidemiology
Genetic Predisposition to Disease
Middle Aged
Myocardial Infarction / epidemiology,  genetics*
Predictive Value of Tests
Prospective Studies
Regression Analysis
Risk Assessment
Risk Factors
Severity of Illness Index
Sex Factors
Stroke / epidemiology,  genetics*
Grant Support
095626//Wellcome Trust; G0500987//Medical Research Council; OSRP2/1006//The Dunhill Medical Trust; RP-PG-0606-1146//Department of Health; //Medical Research Council; //Wellcome Trust

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