| Family history of diabetes and distribution of class II HLA genotypes in children with newly diagnosed type 1 diabetes: effect on diabetic ketoacidosis. | |
| | |
MedLine Citation:
|
PMID: 21890652 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
AbstractObjective: Our purpose was to assess whether family history of diabetes or the HLA DR-DQ genotype of the index case were associated with the frequency of diabetic ketoacidosis (DKA) at diagnosis of childhood type 1 diabetes.Patients and methods: The study cohort comprised 1518 children aged <15 years and diagnosed with type 1 diabetes in Finland in 2002-2005. Family history of type 1 and type 2 diabetes among first-degree relatives (FDR) and grandparents was assessed at diagnosis. HLA DR-DQ genotypes were analyzed using time-resolved fluorometry.Results: In total 12.6% and 1.7% of children had at least one FDR affected with type 1 or type 2 diabetes, respectively, and 6.6% and 34.8% had at least one grandparent with type 1 or type 2 diabetes. DKA (pH<7.30) occurred less frequently in children having a type 1 diabetes affected FDR (7.4% vs. 20.5%, P<0.001). Type 2 diabetes among the parents or grandparents had no such effect. Lower risk HLA genotypes were observed to predispose to DKA (P<0.024). In a logistic regression analysis the risk of DKA was independently associated with the absence of a family member affected by type 1 diabetes, the presence of a low risk HLA genotype and older age at diagnosis (OR 3.23, 1.45 and 1.07, respectively).Conclusion: The presence of type 1 diabetes in a FDR is associated with a decreased risk of DKA at diagnosis. The rate of DKA seems to be higher in children with lower HLA-conferred risk for type 1 diabetes. |
| | |
Authors:
|
Anne Hekkala; Ilonen Jorma; Mikael Knip; Riitta Veijola |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-9-2 |
Journal Detail:
|
Title: European journal of endocrinology / European Federation of Endocrine Societies Volume: - ISSN: 1479-683X ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
|
Created Date: 2011-9-5 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9423848 Medline TA: Eur J Endocrinol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
A Hekkala, Department of pediatrics, University of Oulu, Oulu, Finland. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: REVIEW TOPIC: ENDOCRINE TUMOURS Approach to the patient with advanced differentiated thyroid cancer.
Next Document: A search filter for increasing the retrieval of animal studies in Embase.