Document Detail

Family history of alcohol use disorders among adults with panic disorder in the community.
MedLine Citation:
PMID:  21334007     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Clinical studies suggest a familial association between panic disorder and alcohol use disorders but this relationship has not been examined in a representative community sample. The objective of this study is to examine the familial association between panic disorder and alcohol use disorders among adults in the community.
METHOD: Data were drawn from the NESARC, a nationally representative sample of over 43,000 adults in the United States. Rates of alcohol use disorders were examined using the family history method in first-degree relatives (FDRs) of adults with panic disorder. Analyses were adjusted for demographics, alcohol use disorders in the proband, and anxiety disorders in the FDRs.
RESULTS: First-degree relatives of adults with panic disorder have significantly higher odds of alcohol use disorders, compared with FDRs of adults without panic disorder. These associations persist after adjusting for demographic characteristics, alcohol use disorders in the proband, and anxiety disorders in the FDR's.
CONCLUSIONS: Consistent with findings from clinical studies, this is the first population-based study to show a familial link between panic disorder and alcohol use disorders. This association appears independent of the influence of comorbidity of alcohol use disorders and anxiety disorders, suggesting a potential familial and/or genetic pathway. Future longitudinal studies will be needed to further understand the mechanism of this observed association.
Renee D Goodwin; Joshua D Lipsitz; Katherine Keyes; Sandro Galea; Abby J Fyer
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-02-18
Journal Detail:
Title:  Journal of psychiatric research     Volume:  45     ISSN:  1879-1379     ISO Abbreviation:  J Psychiatr Res     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-07-25     Completed Date:  2011-11-29     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  0376331     Medline TA:  J Psychiatr Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  1123-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
Department of Epidemiology, Mailman School of Public Health, Columbia University, 722 West 168th Street, Rm 1505, New York, NY 10032, USA.
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MeSH Terms
Alcohol-Related Disorders / epidemiology*
Confounding Factors (Epidemiology)
Cross-Sectional Studies
Family Health*
Health Surveys
Middle Aged
Panic Disorder / epidemiology*,  genetics
Reproducibility of Results
Residence Characteristics*
Young Adult
Grant Support
R01 DA-20892/DA/NIDA NIH HHS; R01 DA020892-04/DA/NIDA NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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