Document Detail


Family-based study of brain-derived neurotrophic factor (BDNF) gene polymorphism in alcohol dependence.
MedLine Citation:
PMID:  21098877     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Brain-derived neurotrophic factor (BDNF) belongs to a family of proteins related to the nerve growth factor family, which are responsible for the proliferation, survival and differentiation of neurons. BDNF is thought to be involved in the pathogenesis of bipolar disorder, schizophrenia, eating disorders and addiction. We hypothesize that a functionally relevant polymorphism of the BDNF gene promoter may be associated with the pathogenesis of alcohol dependence. We performed an association study of 141 families with alcohol dependence. One hundred and thirty-eight healthy control subjects were matched based on ethnicity and gender. An association between the BDNF Val66Met gene polymorphism and alcoholism was not found.
Authors:
Anna Grzywacz; Agnieszka Samochowiec; Andrzej Ciechanowicz; Jerzy Samochowiec
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pharmacological reports : PR     Volume:  62     ISSN:  1734-1140     ISO Abbreviation:  Pharmacol Rep     Publication Date:    2010 Sep-Oct
Date Detail:
Created Date:  2010-11-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101234999     Medline TA:  Pharmacol Rep     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  938-41     Citation Subset:  IM    
Affiliation:
Department of Psychiatry, Pomeranian Medical University, Broniewskiego 26, PL71-460 Szczecin, Poland.
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