Document Detail

Family-based association analysis validates chromosome 3p21 as a putative nasopharyngeal carcinoma susceptibility locus.
MedLine Citation:
PMID:  16540749     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Nasopharyngeal carcinoma (NPC) poses one of the serious health problems in southern Chinese, with an incidence rate ranging from 15 to 50/100,000. In our previously linkage analysis, a locus on 3p21 was identified to link to NPC. In this study, family-based association analysis was performed to test the transmission disequilibrium of chromosome 3p in 18 high-risk nasopharyngeal carcinoma families of Hunan province in southern China. METHODS: Single locus and multi-point of transmission disequilibrium test was performed by Genehunter program package with 15 microsatellite markers on chromosome 3p in 18 nasopharyngeal carcinoma pedigrees. RESULTS: A major transmission disequilibrium peak was observed near D3S1568, which possessed 20 alleles or haplotypes of 6 loci, spanning a 12.4 cM region from D3S1298 to D3S1289 on chromosome 3p21.31-3p21.2, and 3 alleles or haplotypes reached high significantly difference (P < 0.01). CONCLUSION: These results reflected a link disequilibrium between this chromosome region and a nasopharyngeal carcinoma susceptibility locus, and provided further evidence that a novel nasopharyngeal carcinoma susceptibility gene may be located in this chromosome region. These alleles or haplotypes transmitting disequilibrium in nasopharyngeal carcinoma pedigrees may act as the highly risk molecular markers after verified in large population.
Zhaoyang Zeng; Yanhong Zhou; Wenling Zhang; Xiaoling Li; Wei Xiong; Huaying Liu; Songqing Fan; Jun Qian; Lili Wang; Zheng Li; Shourong Shen; Guiyuan Li
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Genetics in medicine : official journal of the American College of Medical Genetics     Volume:  8     ISSN:  1098-3600     ISO Abbreviation:  Genet. Med.     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-03-16     Completed Date:  2006-04-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9815831     Medline TA:  Genet Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  156-60     Citation Subset:  IM    
Cancer Research Institute, Central South University, Changsha 410078, Peoples' Republic of China.
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MeSH Terms
Carcinoma / epidemiology,  genetics*,  pathology
Chi-Square Distribution
China / epidemiology
Chromosome Mapping
Chromosomes, Human, Pair 3*
Genetic Markers
Genetic Predisposition to Disease*
Linkage Disequilibrium
Lod Score
Microsatellite Repeats
Nasopharyngeal Neoplasms / epidemiology,  genetics*,  pathology
Polymerase Chain Reaction
Reg. No./Substance:
0/Genetic Markers

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