Document Detail


Family adversity and autonomic reactivity association with immune changes in HIV-affected school children.
MedLine Citation:
PMID:  23766380     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To explore whether primary school entry is associated with changes in immune system parameters in HIV-affected children. HIV-affected children are vulnerable to psychosocial stressors, regardless of their own HIV serological status.
METHODS: Data from 38 HIV-positive and 29 HIV-negative children born to seropositive women were obtained. Measures included family adversity questionnaires, autonomic nervous system (ANS) reactivity, and enumerative and functional changes in peripheral blood immune parameters.
RESULTS: In comparison with children who were HIV-negative, children who were HIV-positive at baseline had fewer CD4(+) T lymphocytes (mean [M] = 916 versus 1206 cells/mm(3) × 10(3); F = 7.8, p = .007), more CD8(+) cells (M = 1046 versus 720 cells/mm(3) × 10(3); F = 7.98, p = .006), and diminished natural killer cell cytotoxicity (M = -0.29 versus 0.41; F = 8.87, p = .004). School entry was associated with changes in immune parameters, but HIV status was not associated with the magnitude of changes. Changes in immune parameters after school entry were associated with family stress and preschool entry ANS reactivity. Highly ANS reactive children had either the greatest increase in CD8(+) cells after school entry or the greatest decrease, depending on reported levels of family adversity (B = 215.35; t = 3.74, p < .001). Changes in functional immune assays were significantly associated with the interactions between HIV status and ANS reactivity.
CONCLUSIONS: These results suggest that autonomic reactivity is associated with increased immunological sensitivity to adverse or challenging social contexts among children affected by HIV.
Authors:
Melanie R Thomas; Diane Wara; Katherine Saxton; Mary Truskier; Margaret A Chesney; W Thomas Boyce
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2013-06-13
Journal Detail:
Title:  Psychosomatic medicine     Volume:  75     ISSN:  1534-7796     ISO Abbreviation:  Psychosom Med     Publication Date:    2013 Jul-Aug
Date Detail:
Created Date:  2013-07-04     Completed Date:  2014-03-10     Revised Date:  2014-07-02    
Medline Journal Info:
Nlm Unique ID:  0376505     Medline TA:  Psychosom Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  557-65     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Autonomic Nervous System / physiopathology*
CD4 Lymphocyte Count
CD4-Positive T-Lymphocytes / immunology
CD8-Positive T-Lymphocytes / immunology
Case-Control Studies
Child
Child, Preschool
Family Conflict / psychology*
Female
HIV Infections / immunology,  physiopathology,  psychology*
Humans
Killer Cells, Natural / immunology
Life Change Events*
Male
Questionnaires
Stress, Psychological / immunology,  physiopathology,  psychology*
Grant Support
ID/Acronym/Agency:
L60 MD006577/MD/NIMHD NIH HHS; R25 MH060482/MH/NIMH NIH HHS
Comments/Corrections

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