Document Detail


Familial uveal melanoma, III. Is the occurrence of familial uveal melanoma coincidental?.
MedLine Citation:
PMID:  8790096     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To ascertain whether the familial occurrence of uveal melanoma was coincidental in kindreds in which 1 first-degree relative of the proband had also been affected with primary uveal melanoma. PATIENTS: In a series of 4500 patients with primary uveal melanoma, 17 kindreds were identified in which a first-degree relative of the proband had also been affected with primary uveal melanoma. DESIGN: In the 17 families in which a first-degree relative of the proband had been affected, primary uveal melanoma was classified as familial. In the remaining 4483 families, primary uveal melanoma was classified as sporadic. The expected number of affected first-degree relatives of probands for a family was estimated, assuming an incidence rate of 6 cases per million population per year in each type of family. RESULTS: The expected number of affected first-degree relatives was calculated to be 0.81, with an SE of 0.08, compared with 17 observed affected first-degree relatives (P < .001). CONCLUSION: Our study provides strong statistical evidence that occurrence of familial uveal melanoma is not coincidental.
Authors:
A D Singh; M X Wang; L A Donoso; C L Shields; P D Potter; J A Shields; R C Elston; B Fijal
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Archives of ophthalmology     Volume:  114     ISSN:  0003-9950     ISO Abbreviation:  Arch. Ophthalmol.     Publication Date:  1996 Sep 
Date Detail:
Created Date:  1996-10-03     Completed Date:  1996-10-03     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7706534     Medline TA:  Arch Ophthalmol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1101-4     Citation Subset:  AIM; IM    
Affiliation:
Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pa, USA.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Child
Child, Preschool
Humans
Incidence
Infant
Infant, Newborn
Melanoma / etiology,  genetics*
Middle Aged
Models, Genetic
Pedigree
Uveal Neoplasms / etiology,  genetics*
Grant Support
ID/Acronym/Agency:
1P41 RR 03655/RR/NCRR NIH HHS; GM 28356/GM/NIGMS NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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