Document Detail


Familial short fifth metacarpals and insulin resistance.
MedLine Citation:
PMID:  16132981     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Very few reports on the phenotype of short fifth metacarpals have been published in the medical literature. We report a Jordanian family in which three sisters aged 15, 13 and 8 years revealed bilateral shortening of the fifth fingers and radiological shortening of the fifth metacarpals. The father had unilateral short fifth metacarpal. The elder two sisters, their father as well as their brother and another sister manifested insulin resistance. Spherocytosis was diagnosed in one of the girls and her father. The parents are non-consanguineous. This constellation of findings has not been previously reported and could point to the presence of two disorders segregating in the family or to a novel syndrome with autosomal dominant inheritance and variable expressivity.
Authors:
Muwafag Hyari; Hanan Hamamy; Muries Barham; Azmy Al-Hadidy; Kamel Ajlouni
Publication Detail:
Type:  Case Reports; Journal Article     Date:  2005-08-13
Journal Detail:
Title:  Skeletal radiology     Volume:  35     ISSN:  0364-2348     ISO Abbreviation:  Skeletal Radiol.     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-08-09     Completed Date:  2007-11-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7701953     Medline TA:  Skeletal Radiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  702-5     Citation Subset:  IM    
Affiliation:
National Center for Diabetes, Endocrinology and Genetics, P.O. Box 13165, 11942 Amman, Jordan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Child
Female
Hand Deformities, Congenital / genetics*,  radiography*
Humans
Insulin Resistance*
Metacarpal Bones / abnormalities*,  radiography
Pedigree

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Multifocal epithelioid hemangioendothelioma of the phalanges of the hand.
Next Document:  Intra-articular fibroma of tendon sheath of the shoulder joint: synovial fibroma.