Document Detail

Familial rheumatoid arthritis: linkage of HLA to disease susceptibility locus in four families where proband presented with juvenile rheumatoid arthritis.
MedLine Citation:
PMID:  6766468     Owner:  NLM     Status:  MEDLINE    
The occurrence of a chronic seronegative polyarthritis has been studied in four families in which the proband presented with some form of juvenile rheumatoid arthritis. In these families, histocompatibility testing suggested that susceptibility to arthritis was controlled by a dominant allele with variable penetrance and expressivity at the rheumatoid-like arthritis, first locus (RLA-1). The combined lod scores for the four families (2.70) indicated that the odds in favor of genetic linkage between the major histocompatibility complex and the postulated disease susceptibility gene, RLA-1, were 500:1. In one family, a recombinant event permitted localization of RLA-1 centromeric to HLA-D. Of major interest was the fact that there was significant pleomorphism in the clinical manifestations of arthritis in affected individuals. In some, symptoms first occurred in childhood and in others, in adult life. Even among those with childhood-onset arthritis, different types of juvenile rheumatoid arthritis were observed within the same family.
R D Rossen; E J Brewer; R M Sharp; J Ott; J W Templeton
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  65     ISSN:  0021-9738     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  1980 Mar 
Date Detail:
Created Date:  1980-04-25     Completed Date:  1980-04-25     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  629-42     Citation Subset:  AIM; IM    
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MeSH Terms
Arthritis, Juvenile Rheumatoid / genetics*,  immunology
Genes, Dominant
Genes, MHC Class II
HLA Antigens / genetics*
Linkage (Genetics)
Middle Aged
Recombination, Genetic
Reg. No./Substance:
0/HLA Antigens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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