Document Detail

Familial relationships in squamous cell carcinoma of the skin.
MedLine Citation:
PMID:  10784249     Owner:  NLM     Status:  MEDLINE    
The Swedish Family-Cancer Database, which was updated in 1999 to cover individuals born after 1934 with their biological parents, totals 9.6 million persons. We used this resource to study invasive and in situ skin cancers. We identified 198 families in which a parent and an offspring had skin cancer. The familial standardized incidence ratios (SIRs) were 2.4 for invasive and 2.8 for in situ skin cancers in offspring. The SIRs for offspring depended only weakly on the age at diagnosis, as evaluated in two age groups. Compared with offspring whose parents had a single skin cancer, offspring whose parents had multiple skin cancers had a 70% increase in SIR. The discordant parental cancer sites that showed associations with skin cancer in offspring were melanoma, ocular melanoma, and a group of cancers observed in immunosuppressed patients.
K Hemminki; C Dong
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Epidemiology (Cambridge, Mass.)     Volume:  11     ISSN:  1044-3983     ISO Abbreviation:  Epidemiology     Publication Date:  2000 May 
Date Detail:
Created Date:  2000-06-08     Completed Date:  2000-06-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9009644     Medline TA:  Epidemiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  309-14     Citation Subset:  IM    
Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden.
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MeSH Terms
Carcinoma, Squamous Cell / epidemiology*,  genetics*
Eye Neoplasms / genetics
Genetic Predisposition to Disease
Melanoma / genetics
Middle Aged
Skin Neoplasms / epidemiology*,  genetics*
Sweden / epidemiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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