| Familial pityriasis rubra pilaris: report of a family and therapeutic response to etanercept. | |
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MedLine Citation:
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PMID: 20677542 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pityriasis rubra pilaris (PRP) is an uncommon dermatosis of unknown etiology. The familial subtype is rare and usually presents as type V PRP. It is generally inherited in an autosomal dominant fashion with variable expression. Other forms of inheritance, such as autosomal recessive and X-linked, have also been reported. The use of etanercept in treating resistant forms of PRP is promising given reports of its success in a few cases. Herein, the authors report two cases of PRP arising in a mother and son and review the rare familial subtype of this disease. In addition, a successful therapeutic trial of etanercept was initiated in the mother based on case reports of its efficacy in other patients with PRP. |
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Authors:
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Marie Vasher; Erica Smithberger; Mary H Lien; Neil Alan Fenske |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of drugs in dermatology : JDD Volume: 9 ISSN: 1545-9616 ISO Abbreviation: J Drugs Dermatol Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-08-03 Completed Date: 2010-08-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101160020 Medline TA: J Drugs Dermatol Country: United States |
Other Details:
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Languages: eng Pagination: 844-50 Citation Subset: IM |
Affiliation:
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Department of Dermatology and Cutaneous Surgery, University of South Florida,Tampa, FL 33612, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Diagnosis, Differential Female Humans Immunoglobulin G / therapeutic use* Male Middle Aged Pityriasis Rubra Pilaris / drug therapy*, genetics*, pathology Receptors, Tumor Necrosis Factor / therapeutic use* Tumor Necrosis Factor-alpha / antagonists & inhibitors* |
| Chemical | |
Reg. No./Substance:
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0/Immunoglobulin G; 0/Receptors, Tumor Necrosis Factor; 0/Tumor Necrosis Factor-alpha; 185243-69-0/TNFR-Fc fusion protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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