Document Detail


Familial pityriasis rubra pilaris: report of a family and therapeutic response to etanercept.
MedLine Citation:
PMID:  20677542     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pityriasis rubra pilaris (PRP) is an uncommon dermatosis of unknown etiology. The familial subtype is rare and usually presents as type V PRP. It is generally inherited in an autosomal dominant fashion with variable expression. Other forms of inheritance, such as autosomal recessive and X-linked, have also been reported. The use of etanercept in treating resistant forms of PRP is promising given reports of its success in a few cases. Herein, the authors report two cases of PRP arising in a mother and son and review the rare familial subtype of this disease. In addition, a successful therapeutic trial of etanercept was initiated in the mother based on case reports of its efficacy in other patients with PRP.
Authors:
Marie Vasher; Erica Smithberger; Mary H Lien; Neil Alan Fenske
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of drugs in dermatology : JDD     Volume:  9     ISSN:  1545-9616     ISO Abbreviation:  J Drugs Dermatol     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-08-03     Completed Date:  2010-08-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101160020     Medline TA:  J Drugs Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  844-50     Citation Subset:  IM    
Affiliation:
Department of Dermatology and Cutaneous Surgery, University of South Florida,Tampa, FL 33612, USA.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Diagnosis, Differential
Female
Humans
Immunoglobulin G / therapeutic use*
Male
Middle Aged
Pityriasis Rubra Pilaris / drug therapy*,  genetics*,  pathology
Receptors, Tumor Necrosis Factor / therapeutic use*
Tumor Necrosis Factor-alpha / antagonists & inhibitors*
Chemical
Reg. No./Substance:
0/Immunoglobulin G; 0/Receptors, Tumor Necrosis Factor; 0/Tumor Necrosis Factor-alpha; 185243-69-0/TNFR-Fc fusion protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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