| Familial occurrence of narcolepsy in miniature horses. | |
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MedLine Citation:
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PMID: 7903939 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In an investigation of 2 closely related Miniature Horses with a history of excessive sleepiness, depression and episodes of collapse, a diagnosis of narcolepsy was made on the basis of neurological examination and pharmacological testing. Further investigations included electroencephalographic examination (EEG), and analysis of protein content, cell count and monoamine metabolite concentrations of lumbosacral cerebrospinal fluid (CSF). There were no abnormalities noted in the EEGs, and no consistent changes in CSF neurotransmitter metabolites in the narcoleptic horses when compared with 3 normal, unrelated Miniature Horses and 2 related, clinically unaffected animals. The breeding background of the 2 affected horses was investigated and a limited survey of Miniature Horse breeders in North America was conducted. These investigations have shown that narcolepsy is a rare but distinct syndrome in the Miniature Horse, and that the cases described here appear to represent a familial occurrence of the disease. |
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Authors:
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D P Lunn; P A Cuddon; S Shaftoe; R M Archer |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Equine veterinary journal Volume: 25 ISSN: 0425-1644 ISO Abbreviation: Equine Vet. J. Publication Date: 1993 Nov |
Date Detail:
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Created Date: 1994-02-09 Completed Date: 1994-02-09 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0173320 Medline TA: Equine Vet J Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 483-7 Citation Subset: IM |
Affiliation:
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School of Veterinary Medicine, University of Wisconsin, Madison 53706. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Atropine / diagnostic use Breeding Electroencephalography / veterinary Female Horse Diseases / diagnosis, genetics* Horses Imipramine / diagnostic use Male Narcolepsy / diagnosis, genetics, veterinary* Neostigmine / diagnostic use Neurologic Examination / veterinary Neurotransmitter Agents / cerebrospinal fluid Pedigree Physostigmine / analogs & derivatives, diagnostic use |
| Chemical | |
Reg. No./Substance:
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0/Neurotransmitter Agents; 50-49-7/Imipramine; 51-55-8/Atropine; 57-47-6/Physostigmine; 57-64-7/physostigmine salicylate; 59-99-4/Neostigmine |
| Comments/Corrections | |
Comment In:
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Equine Vet J. 1993 Nov;25(6):476-7
[PMID:
8275992
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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