Document Detail


Familial occurrence of brain arteriovenous malformations: a systematic review.
MedLine Citation:
PMID:  17259353     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Brain arteriovenous malformations (BAVMs) are thought to be sporadic developmental vascular lesions, but familial occurrence has been described. We compared the characteristics of patients with familial BAVMs with those of patients with sporadic BAVMs.
METHODS: We systematically reviewed the literature on patients with familial BAVMs. Three families that were found in our centre were added. Age, sex distribution and clinical presentation of the identified patients were compared with those in population based series of patients with sporadic BAVMs. Furthermore, we calculated the difference in mean age at diagnosis of parents and children to study possible anticipation.
RESULTS: We identified 53 patients in 25 families with BAVMs. Mean age at diagnosis of patients with familial BAVMs was 27 years (range 9 months to 58 years), which was younger than in the reference population (difference between means 8 years, 95% CI 3 to 13 years). Patients with familial BAVMs did not differ from the reference populations with respect to sex or mode of presentation. In families with BAVMs in successive generations, the age of the child at diagnosis was younger than the age of the parent (difference between means 22 years, 95% CI 13 to 30 years), which suggests clinical anticipation.
CONCLUSIONS: Few patients with familial BAVMs have been described. These patients were diagnosed at a younger age than sporadic BAVMs whereas their mode of presentation was similar. Although there are indications of anticipation, it remains as yet unclear whether the described families represent accidental aggregation or indicate true familial occurrence of BAVMs.
Authors:
J van Beijnum; H B van der Worp; H M Schippers; O van Nieuwenhuizen; L J Kappelle; G J E Rinkel; J W Berkelbach van der Sprenkel; C J M Klijn
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2007-01-26
Journal Detail:
Title:  Journal of neurology, neurosurgery, and psychiatry     Volume:  78     ISSN:  1468-330X     ISO Abbreviation:  J. Neurol. Neurosurg. Psychiatr.     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-10-17     Completed Date:  2007-11-01     Revised Date:  2013-06-06    
Medline Journal Info:
Nlm Unique ID:  2985191R     Medline TA:  J Neurol Neurosurg Psychiatry     Country:  England    
Other Details:
Languages:  eng     Pagination:  1213-7     Citation Subset:  IM    
Affiliation:
Department of Neurosurgery, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, The Netherlands. J.vanBeijnum@umcutrecht.nl
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Anticipation, Genetic / genetics
Child
Child, Preschool
Female
Humans
Infant
Intracranial Arteriovenous Malformations / diagnosis,  genetics*
Male
Middle Aged
Telangiectasia, Hereditary Hemorrhagic / diagnosis,  genetics
Transforming Growth Factor beta / genetics
Chemical
Reg. No./Substance:
0/Transforming Growth Factor beta
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