| Familial occurrence of Turner syndrome: casual event or increased risk? | |
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MedLine Citation:
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PMID: 21648298 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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AIM: The prevalence of Turner syndrome (TS) at birth has been estimated as approximately 1 in 2500 live female births. An increased risk of TS in subsequent pregnancies for couples who already have a daughter with TS has not been reported. METHODS: We reviewed the records of 140 patients to evaluate the presence of familial TS occurrence. RESULTS: Recurrence of TS was observed in 1.4% of our case series, which represents a 35-fold increased probability of having a second child with TS compared to no recurrence. CONCLUSION: This observation suggests that a risk of recurrence is possible, even though it is generally assumed that the likelihood of recurrent pregnancies with TS is similar to that in the general population. A wider study would be useful to confirm these data to improve genetic counseling for families with a daughter with TS. |
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Authors:
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Daniela Larizza; Cesare Danesino; Paola Maraschio; Claudia Caramagna; Catherine Klersy; Valeria Calcaterra |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of pediatric endocrinology & metabolism : JPEM Volume: 24 ISSN: 0334-018X ISO Abbreviation: J. Pediatr. Endocrinol. Metab. Publication Date: 2011 |
Date Detail:
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Created Date: 2011-06-08 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9508900 Medline TA: J Pediatr Endocrinol Metab Country: England |
Other Details:
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Languages: eng Pagination: 223-5 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, University of Pavia and IRCCS Policlinico San Matteo Foundation, Pavia, Italy. d.larizza@smatteo.pv.it |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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