| Familial non-rcd1 generalised retinal degeneration in Irish setters. | |
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MedLine Citation:
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PMID: 12653325 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Four Irish setters were diagnosed with bilateral retinal degeneration and cataracts at an age ranging from six to 11 years. In three of these dogs, progressive night blindness was reported from an age of eight to 11 years. In the fourth dog, aged six, no signs of visual impairment had been noticed. In all four dogs, the rod-cone dysplasia type 1 (rcd1) mutation was excluded as a cause, using an allele-specific PCR. From their three-generation pedigrees, a familial relationship was detected in three out of four dogs, which were also related to four additional Irish setter dogs with a history and clinical signs suggestive of late-onset progressive retinal degeneration. These results suggest the existence of a possibly hereditary, late-onset, progressive retinal atrophy in the Irish setter breed, that is distinct from rcd1. |
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Authors:
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S C Djajadiningrat-Laanen; M H Boevé; F C Stades; B A van Oost |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of small animal practice Volume: 44 ISSN: 0022-4510 ISO Abbreviation: J Small Anim Pract Publication Date: 2003 Mar |
Date Detail:
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Created Date: 2003-03-25 Completed Date: 2003-04-24 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0165053 Medline TA: J Small Anim Pract Country: England |
Other Details:
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Languages: eng Pagination: 113-6 Citation Subset: IM |
Affiliation:
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Department of Companion Animal Medicine, Faculty of Veterinary Medicine, Utrecht University, PO Box 80154, 3508 TD Utrecht, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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3',5'-Cyclic-GMP Phosphodiesterases
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genetics Animals DNA Primers Dog Diseases / genetics* Dogs Female Genetic Predisposition to Disease Male Mutation Netherlands Pedigree Polymerase Chain Reaction / veterinary Records as Topic / veterinary Retinal Dysplasia / genetics, veterinary* Retrospective Studies |
| Chemical | |
Reg. No./Substance:
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0/DNA Primers; EC 3.1.4.35/3',5'-Cyclic-GMP Phosphodiesterases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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