| Familial multiple sclerosis: does consanguinity have a role? | |
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MedLine Citation:
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PMID: 21177327 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Parental consanguinity (PC) may be a risk factor for familial multiple sclerosis (FMS) throughout inbred communities. The objective of this report was to estimate prevalence of FMS and rate of PC among FMS versus non-FMS patients. All Saudi MS patients were identified from our registry. The history of PC was analyzed as a case-control study. In total 141 MS patients were identified. Of these, 30 (21%) reported having at least one affected relative, 37.6% reported PC and 16% presented first-degree PC. In addition, FMS patients were more likely than non-FMS patients to report PC. In conclusion, FMS is prevalent among Saudi MS patients. MS patients with a history of PC were more likely to have FMS, suggesting a potential role of consanguinity. |
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Authors:
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M Al Jumah; S Kojan; A Al Khaathami; I Al Abdulkaream; M Al Blawi; A Jawhary |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2010-12-21 |
Journal Detail:
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Title: Multiple sclerosis (Houndmills, Basingstoke, England) Volume: - ISSN: 1477-0970 ISO Abbreviation: - Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-12-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9509185 Medline TA: Mult Scler Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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King Abdullah International Medical Research Center, KSAU-HS, Riyadh, Saudi Arabia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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