Document Detail

Familial mesothelioma. Details of 17 cases with histopathologic findings and mineral analysis.
MedLine Citation:
PMID:  1515995     Owner:  NLM     Status:  MEDLINE    
Nine new cases of mesothelioma clustering in four families are described, and additional information is provided on four previously reported families. All of the members of these families had some exposure to asbestos. Diagnoses were confirmed histologically, and the relevance of the histologic pattern is discussed after the literature review. The lung mineral fiber burden was quantified in patients by transmission electron microscopic examination and energy-dispersive x-ray analysis, and this confirmed significant exposure to amphibole asbestos in all patients. Evidence supporting an increased incidence of mesothelioma in family members is discussed.
A Dawson; A Gibbs; K Browne; F Pooley; M Griffiths
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Cancer     Volume:  70     ISSN:  0008-543X     ISO Abbreviation:  Cancer     Publication Date:  1992 Sep 
Date Detail:
Created Date:  1992-10-07     Completed Date:  1992-10-07     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0374236     Medline TA:  Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1183-7     Citation Subset:  AIM; IM    
Environmental Lung Disease Research Group, Llandough Hospital, Penarth, United Kingdom.
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MeSH Terms
Asbestos / adverse effects,  analysis,  pharmacokinetics
Body Burden
Family Health
Lung / chemistry,  metabolism
Lung Neoplasms / etiology,  genetics*,  pathology
Mesothelioma / etiology,  genetics*,  pathology
Microscopy, Electron
Middle Aged
Minerals / analysis*
Reg. No./Substance:
0/Minerals; 1332-21-4/Asbestos

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