Document Detail

Familial hypotrichosis of the scalp. Autosomal dominant inheritance in four generations.
MedLine Citation:
PMID:  1681656     Owner:  NLM     Status:  MEDLINE    
We describe a Danish family of four generations suffering from hypotrichosis of the scalp. Age at onset was 6-17 years and almost total scalp alopecia was reached by the age of 14-21 years. No associated ectodermal defects were present. Nine of 22 persons covering four generations were affected. Growth of the scalp hair slowly decreased and was accompanied by a gradual, diffuse hair loss without regional variation. A scalp biopsy was performed, revealing a non-scarring alopecia with features of androgenetic alopecia. The pedigree was compatible with autosomal dominant inheritance.
H H Ibsen; O J Clemmensen; F Brandrup
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta dermato-venereologica     Volume:  71     ISSN:  0001-5555     ISO Abbreviation:  Acta Derm. Venereol.     Publication Date:  1991  
Date Detail:
Created Date:  1991-11-05     Completed Date:  1991-11-05     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370310     Medline TA:  Acta Derm Venereol     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  349-51     Citation Subset:  IM    
Department of Dermatology, Odense University Hospital, Denmark.
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MeSH Terms
Age Factors
Aged, 80 and over
Genes, Dominant / genetics
Hair / pathology
Hypotrichosis / genetics*,  pathology
Scalp / pathology*

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