Document Detail

Familial history of type 2 diabetes in patients from Southern Brazil and its influence on the clinical characteristics of this disease.
MedLine Citation:
PMID:  17160209     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate the presence of maternal and paternal history of type 2 diabetes mellitus (DM) in relatives of 644 type 2 diabetic patients from Southern Brazil, and also to evaluate its influence on the clinical characteristics of this disease. PATIENTS AND METHODS: Familial history of type 2 DM was investigated by a questionnaire. The maternal and paternal history was investigated over two generations. Complete data sets on familial history were obtained from 396 patients. RESULTS: In general, 76.6% of the patients reported at least one first-degree affected relative. Besides, 31.6% of the patients reported a maternal history of type 2 DM and 12.6% reported a paternal history. Patients with maternal and/or paternal history presented a lower age at type 2 DM diagnosis when compared to patients without familial history. In addition, patients with only paternal history presented a higher frequency of hypertension than patients with no familial history. CONCLUSIONS: This study suggests that there is a significant maternal effect in the transmission of type 2 DM in Southern Brazil, and that most of the clinical characteristics of this disease do not differ between patients with or without familial history of type 2 DM.
Daisy Crispim; Luís H Canani; Jorge L Gross; Balduíno Tschiedel; Kátia E P Souto; Israel Roisenberg
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Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Arquivos brasileiros de endocrinologia e metabologia     Volume:  50     ISSN:  0004-2730     ISO Abbreviation:  Arq Bras Endocrinol Metabol     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-12-12     Completed Date:  2007-10-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0403437     Medline TA:  Arq Bras Endocrinol Metabol     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  862-8     Citation Subset:  IM    
Departamento de Genetica, Universidade Federal do Rio Grande do Sul.
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MeSH Terms
African Continental Ancestry Group / genetics
Age of Onset
Albuminuria / urine
Blood Glucose / analysis
Brazil / ethnology
Diabetes Mellitus, Type 2 / ethnology,  genetics*
Epidemiologic Methods
European Continental Ancestry Group / genetics
Medical History Taking
Middle Aged
Reg. No./Substance:
0/Blood Glucose
Comment In:
Arq Bras Endocrinol Metabol. 2006 Oct;50(5):833-5   [PMID:  17160204 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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