Document Detail

Familial hemophagocytic lymphohistiocytosis and X-linked lymphoproliferative disease.
MedLine Citation:
PMID:  22129058     Owner:  NLM     Status:  MEDLINE    
Familial hemophagocytic lymphohistiocytosis and X-linked lymphoproliferative disease are rare, fatal, inherited immune deficiency disorders. Both diagnoses are used to describe patients who are affected by several known or presumed genetic mutations that, in common, predispose patients to the development of hemophagocytic lymphohistiocytosis. Many pivotal advances have been made in recent years with regard to our understanding and treatment of these diseases. Here, we will describe the genetic and functional bases of these diseases, highlight their clinical manifestations, and discuss current diagnostic and therapeutic strategies.
Rebecca A Marsh; Alexandra H Filipovich
Related Documents :
24454008 - Sunitinib treatment for metastatic renal cell carcinoma in patients with von hippel-lin...
23314528 - The role of ser129 phosphorylation of α-synuclein in neurodegeneration of parkinson's ...
21903338 - Mycobacterium paratuberculosis and autism: is this a trigger?
22251008 - Alternative medicines as emerging therapies for inflammatory bowel diseases.
25394298 - Laminations and microgranule formation in pediatric glomerular basement membranes.
3794928 - Congenital diarrhea with intestinal inflammation and epithelial immaturity.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of the New York Academy of Sciences     Volume:  1238     ISSN:  1749-6632     ISO Abbreviation:  Ann. N. Y. Acad. Sci.     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-12-01     Completed Date:  2012-01-27     Revised Date:  2012-02-15    
Medline Journal Info:
Nlm Unique ID:  7506858     Medline TA:  Ann N Y Acad Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  106-21     Citation Subset:  IM    
Copyright Information:
© 2011 New York Academy of Sciences.
Division of Bone Marrow Transplantation and Immune Deficiency, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Ohio 45229, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Lymphohistiocytosis, Hemophagocytic / diagnosis*,  genetics,  therapy
Lymphoproliferative Disorders / diagnosis*,  genetics,  therapy
Erratum In:
Ann N Y Acad Sci. 2011 Dec;1246:141

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Newborn screening for SCID: three years of experience.
Next Document:  Hematopoietic stem cell transplantation for primary immunodeficiency diseases.