| Familial hemifacial spasm: report of cases and review of literature. | |
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MedLine Citation:
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PMID: 11790389 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We describe clinical characteristics of 10 patients (five families) with familial hemifacial spasm, with reviews of 13 patients hitherto reported in the literature. There is no clear difference in clinical manifestations between sporadic and familial hemifacial spasms. There is no definite inheritance pattern, but may be autosomal dominant with low penetrance. The ages of onset of familial hemifacial spasm are variable, but occasionally can occur at early years of life. There is a left-side predominance with respect to the affected side of cases with familial hemifacial spasm. Similar to sporadic hemifacial spasm, vascular decompression was effective, suggesting that vascular compression is involved in generating hemifacial spasm even in the familial cases. Familial hemifacial spasm may not be a rare disorder, but may possibly be overlooked. Clarifying the role of genetic susceptibility in pathophysiological mechanisms underlying hemifacial spasm is an important approach toward better understanding of the pathogenesis of cranial rhizopathies. |
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Authors:
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Hideto Miwa; Yoshikuni Mizuno; Tomoyoshi Kondo |
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Publication Detail:
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Type: Case Reports; Journal Article; Review |
Journal Detail:
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Title: Journal of the neurological sciences Volume: 193 ISSN: 0022-510X ISO Abbreviation: J. Neurol. Sci. Publication Date: 2002 Jan |
Date Detail:
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Created Date: 2002-01-15 Completed Date: 2002-03-20 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375403 Medline TA: J Neurol Sci Country: Netherlands |
Other Details:
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Languages: eng Pagination: 97-102 Citation Subset: IM |
Affiliation:
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Department of Neurology, Wakayama Medical University, 811-1 Kimiidera, Wakayama 641-8510, Japan. h-miwa@wakayama-med.ac.jp |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age of Onset Aged Aged, 80 and over Botulinum Toxin Type A / therapeutic use Decompression, Surgical Facial Nerve / drug effects, physiopathology*, surgery Facial Nerve Diseases / genetics*, physiopathology*, therapy Family Health* Female Functional Laterality / genetics Genetic Predisposition to Disease / genetics Hemifacial Spasm / genetics*, physiopathology*, therapy Humans Male Middle Aged Pedigree Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Botulinum Toxin Type A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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