| Familial hemifacial spasm and determinants of late onset. | |
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MedLine Citation:
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PMID: 19812891 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The role of hypertension in the late onset of hemifacial spasm (HFS) is evaluated in a family, spanning four generations. Magnetic resonance imaging (MRI) and magnetic resonance angiography (MRA) revealed a variable anatomical relationship between nervous and vascular structures in the symptomatic cerebello-pontine angle. In one case, showing neurovascular conflict (NVC), microvascular surgical decompression was followed by clinical resolution of HFS. Neuroimaging suggesting NVC was found in all symptomatic patients of the last two generations and in three younger subjects not affected by HFS. As a determinant for the late development of clinical expression is reviewed the role of arterial hypertension, detected few years before HFS appearing in all symptomatic subjects. The distribution of NVC in several members of the same family suggests a genetic susceptibility towards vascular anomaly. |
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Authors:
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Giovanni Lagalla; Francesco Logullo; Paolo Di Bella; Ramazan Haghighipour; Leandro Provinciali |
Publication Detail:
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Type: Journal Article Date: 2009-10-08 |
Journal Detail:
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Title: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology Volume: 31 ISSN: 1590-3478 ISO Abbreviation: Neurol. Sci. Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-01-26 Completed Date: 2010-04-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100959175 Medline TA: Neurol Sci Country: Italy |
Other Details:
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Languages: eng Pagination: 17-22 Citation Subset: IM |
Affiliation:
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Clinica Neurologica, Dipartimento di Scienze Neurologiche, Az. Ospedali Riuniti, Universit? Politecnica delle Marche, via Conca 1, 60020, Ancona, Italy. lagallag@yahoo.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age of Onset Aged Aged, 80 and over Brain / blood supply, pathology Cerebral Angiography Electromyography Facial Nerve / physiopathology Family Female Genetic Predisposition to Disease Hemifacial Spasm / genetics, pathology*, physiopathology Humans Intracranial Hypertension / genetics, pathology*, physiopathology Magnetic Resonance Angiography Magnetic Resonance Imaging Male Middle Aged Pedigree |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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