Document Detail


Familial and genetic susceptibility to major neonatal morbidities in preterm twins.
MedLine Citation:
PMID:  16740829     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Intraventricular hemorrhage, necrotizing enterocolitis, and bronchopulmonary dysplasia remain significant causes of morbidity and mortality in preterm newborns. OBJECTIVES: Our goal was to assess the familial and genetic susceptibility to intraventricular hemorrhage, necrotizing enterocolitis, and bronchopulmonary dysplasia. METHODS: Mixed-effects logistic-regression and latent variable probit model analysis were used to assess the contribution of several covariates in a multicenter retrospective study of 450 twin pairs born at < or =32 weeks of gestation. To determine the genetic contribution, concordance rates in a subset of 252 monozygotic and dizygotic twin pairs were compared. RESULTS: The study population had a mean gestational age of 29 weeks and birth weight of 1286 g. After controlling for effects of covariates, the twin data showed that 41.3%, 51.9%, and 65.2%, respectively, of the variances in liability for intraventricular hemorrhage, necrotizing enterocolitis, and bronchopulmonary dysplasia could be accounted for by genetic and shared environmental factors. Among the 63 monozygotic twin pairs, the observed concordance for bronchopulmonary dysplasia was significantly higher than the expected concordance; 12 of 18 monozygotic twin pairs with > or =1 affected member had both members affected versus 3.69 expected. After controlling for covariates, genetic factors accounted for 53% of the variance in liability for bronchopulmonary dysplasia. CONCLUSIONS: Twin analyses show that intraventricular hemorrhage, necrotizing enterocolitis, and bronchopulmonary dysplasia are familial in origin. These data demonstrate, for the first time, the significant genetic susceptibility for bronchopulmonary dysplasia in preterm infants.
Authors:
Vineet Bhandari; Matthew J Bizzarro; Anupama Shetty; Xiaoyun Zhong; Grier P Page; Heping Zhang; Laura R Ment; Jeffrey R Gruen;
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Twin Study    
Journal Detail:
Title:  Pediatrics     Volume:  117     ISSN:  1098-4275     ISO Abbreviation:  Pediatrics     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-06-02     Completed Date:  2006-06-26     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1901-6     Citation Subset:  AIM; IM    
Affiliation:
Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520-8064, USA.
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MeSH Terms
Descriptor/Qualifier:
Bronchopulmonary Dysplasia / genetics*
Cerebral Hemorrhage / genetics*
Diseases in Twins / genetics*
Enterocolitis, Necrotizing / genetics*
Female
Genetic Predisposition to Disease*
Humans
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases / genetics*
Male
Retrospective Studies
Grant Support
ID/Acronym/Agency:
DA016750/DA/NIDA NIH HHS; DA017713/DA/NIDA NIH HHS; K08 HL 074195/HL/NHLBI NIH HHS; NS 27116/NS/NINDS NIH HHS; NS 35476/NS/NINDS NIH HHS; NS 42027/NS/NINDS NIH HHS; NS 43530/NS/NINDS NIH HHS; R01DA12468/DA/NIDA NIH HHS; T32 HD 07094/HD/NICHD NIH HHS
Comments/Corrections
Comment In:
Pediatrics. 2006 Jun;117(6):2285-6   [PMID:  16740878 ]

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