| Familial dysgerminoma associated with 46, XX pure gonadal dysgenesis. | |
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MedLine Citation:
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PMID: 15951888 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although the occurrence of pure gonadal dysgenesis PGD is usually sporadic and nonfamilial, here we present 3 sisters with 46, XX PGD, who are born from a first cousin marriage. Review of their family pedigree is compatible with autosomal recessive inheritance. Surprisingly, 2 of these sisters developed ovarian tumors. Both showed the pathological result of dysgerminoma with syncytiotrophoblastic giant cells. These 2 cases are examples of tumorigenesis in PGD without an identifiable Y chromosome. Therefore, malignant degeneration of the streak gonads should be considered in the patients with 46, XX PGD. |
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Authors:
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Bahia Namavar-Jahromi; Mitra Mohit; Perikala V Kumar |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Saudi medical journal Volume: 26 ISSN: 0379-5284 ISO Abbreviation: Saudi Med J Publication Date: 2005 May |
Date Detail:
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Created Date: 2005-06-13 Completed Date: 2006-08-23 Revised Date: 2008-06-23 |
Medline Journal Info:
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Nlm Unique ID: 7909441 Medline TA: Saudi Med J Country: Saudi Arabia |
Other Details:
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Languages: eng Pagination: 872-4 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Shiraz Univeristy of Medical Sciences, Iran. namavarb@sums.ac.ir |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Chromosome Disorders Consanguinity Dysgerminoma / complications*, pathology Female Genes, Recessive Giant Cells / pathology* Gonadal Dysgenesis, 46,XX / complications*, genetics Humans Iran Ovarian Neoplasms / complications* Trophoblasts / pathology |
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