| Familial clustering of diabetic retinopathy in Chongqing, China, type 2 diabetic patients. | |
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MedLine Citation:
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PMID: 20306445 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To investigate whether there is familial aggregation of diabetic retinopathy (DR) among type 2 diabetes mellitus (T2DM) patients in Chongqing, the municipality in southwest China. METHODS: From December 2004 to December 2006, 167 T2DM families with at least 2 diabetic siblings were investigated. In all 414 subjects, the sibling with the longest duration of diabetes was defined as the proband. The occurrence of retinopathy was compared between the siblings of probands with and without retinopathy. DR risk factors of the siblings of probands were studied by multiple logistic regression analysis. RESULTS: DR was diagnosed in 7.1% of the siblings of the probands without DR and in 29.7% of the siblings of the probands with DR. The difference reached statistical significance in probands with DR and probands without DR (p<0.0001). Nonesterified fatty acid (NEFA) was a risk factor for DR (odds ratio = 2.108, 95% confidence interval 1.077-4.127). It appeared that regardless of probands with DR, siblings with history of smoking had less risk for developing DR than those with no history of smoking. CONCLUSIONS: Familial clustering of DR existed in the patients with T2DM in Chongqing, China. In DR siblings, NEFA is a risk factor of DR, while smoking may reduce DR occurrence. |
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Authors:
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Xuedong Zhang; Yan Gao; Zhongqiang Zhou; Jing Wang; Qingyun Zhou; Qi Li |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of ophthalmology Volume: 20 ISSN: 1724-6016 ISO Abbreviation: Eur J Ophthalmol Publication Date: 2010 Sep-Oct |
Date Detail:
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Created Date: 2010-08-02 Completed Date: 2010-10-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9110772 Medline TA: Eur J Ophthalmol Country: Italy |
Other Details:
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Languages: eng Pagination: 911-8 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology, The 1st Affiliated Hospital, Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology, Chongqing, China. zxued@sina.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Asian Continental Ancestry Group
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genetics* Blood Glucose / analysis China / epidemiology Cluster Analysis Diabetes Mellitus, Type 2 / epidemiology, genetics* Diabetic Retinopathy / epidemiology, genetics* Fatty Acids, Nonesterified / blood Female Humans Male Middle Aged Regression Analysis Risk Factors Siblings Smoking / epidemiology |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Fatty Acids, Nonesterified |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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