Document Detail

Familial cheiroarthropathy without juvenile onset diabetes mellitus.
MedLine Citation:
PMID:  7163735     Owner:  NLM     Status:  MEDLINE    
Cheiroarthropathy is a recently recognised complication of juvenile onset diabetes mellitus. It comprises inability to extend fully the fingers, contracted tendons, and waxy thickening of the skin overlying the fingers and to a lesser extent the hands. We report two families in which one parent and a number of siblings had the typical features of cheiroarthropathy without juvenile onset diabetes mellitus. The changes developed gradually during childhood and did not progress after adolescence. There were no other abnormal clinical findings, no persistently abnormal laboratory tests, and no association with a specific HLA phenotype. There are some similarities with scleroderma and its recognition is important to prevent unnecessary treatment and to reassure patients.
D L Scott; J P Delamere; L P Mackintosh; S Jobson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Rheumatology international     Volume:  2     ISSN:  0172-8172     ISO Abbreviation:  Rheumatol. Int.     Publication Date:  1982  
Date Detail:
Created Date:  1983-04-15     Completed Date:  1983-04-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8206885     Medline TA:  Rheumatol Int     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  141-3     Citation Subset:  IM    
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MeSH Terms
Complement C3 / analysis
Complement C4 / analysis
Diabetes Mellitus, Type 1 / genetics,  immunology
HLA Antigens / analysis
Hand Deformities, Acquired / genetics*
Joint Diseases / genetics*
Middle Aged
Scleroderma, Systemic / genetics,  immunology
Reg. No./Substance:
0/Complement C3; 0/Complement C4; 0/HLA Antigens

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