Document Detail

Familial atrial tachyarrhythmia with short PR interval.
MedLine Citation:
PMID:  836114     Owner:  NLM     Status:  MEDLINE    
A family had an unusual and perhaps unique familial dysrhythmia. The proband had a short PR interval with normal QRS and chronic recurrent paroxysmal atrial tachycardia (Lown-Ganong-Levine syndrome). The arrhythmia produced left ventricular dysfunction. Both paroxysmal atrial tachycardia (PAT) and left ventricular dysfunction were reversed with administration of digoxin and propranolol hydrochloride. Three family members had paroxysmal or chronic atrial fibrillation, first diagnosed at a relatively young age (23 years, 38 years, and early 40s, respectively). Five additional family members had short PR intervals with normal QRS, and eight other family members had borderline short PR intervals. The mode of inheritance appeared to be autosomal dominant with varying expressivity. We have described a familial syndrome characterized by PAT or atrial fibrillation in its advanced form with short PR interval as a possible identifying trait. The future course of members with isolated short PR is unknown.
M Brodsky; D Wu; P Denes; K M Rosen
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Archives of internal medicine     Volume:  137     ISSN:  0003-9926     ISO Abbreviation:  Arch. Intern. Med.     Publication Date:  1977 Feb 
Date Detail:
Created Date:  1977-03-31     Completed Date:  1977-03-31     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372440     Medline TA:  Arch Intern Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  165-9     Citation Subset:  AIM; IM    
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MeSH Terms
Arrhythmias, Cardiac / diagnosis,  drug therapy,  genetics*
Digoxin / therapeutic use
Heart Atria
Propranolol / therapeutic use
Tachycardia, Paroxysmal / diagnosis,  drug therapy,  genetics*
Reg. No./Substance:
20830-75-5/Digoxin; 525-66-6/Propranolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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