Document Detail

Familial association of congenital left heart abnormalities and sustained fetal arrhythmia.
MedLine Citation:
PMID:  10441694     Owner:  NLM     Status:  MEDLINE    
Hypoplastic left heart syndrome (HLHS) is the most common cause of death from heart disease in the first week of life. There are reports about familial concordance by presumed morphogenetic mechanisms of abnormal embryonic blood flow with phenotypes of varying severity. The risk of having a child with a left heart lesion after a previously affected child may be as high as 5% to 12%. We present case reports from four families in which sustained fetal arrhythmia (three ectopic atrial tachycardias and one severe bradycardia due to excessive ectopic atrial beats) was demonstrated. Within these four families a close relative of the mother (a previous child, a brother, or a nephew) had severe left heart abnormality (three with HLHS and one with severe aortic valve stenosis). The association of sustained fetal arrhythmia of ectopic atrial origin and severe left heart abnormalities could be expected to occur by chance in a very low percentage of cases. We conclude that sustained fetal atrial ectopic arrhythmia is a congenital abnormality and should be considered as a risk factor for inherited congenital heart abnormalities.
J Hajdú; T Marton; E Tóth-Pál; Z Papp
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Pediatric cardiology     Volume:  20     ISSN:  0172-0643     ISO Abbreviation:  Pediatr Cardiol     Publication Date:    1999 Sep-Oct
Date Detail:
Created Date:  1999-09-02     Completed Date:  1999-09-02     Revised Date:  2008-02-20    
Medline Journal Info:
Nlm Unique ID:  8003849     Medline TA:  Pediatr Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  368-70     Citation Subset:  IM    
1st Department of Obstetrics and Gynecology, Semmelweis University Medical School, Budapest H-1088, Baross Strasse 27, Hungary.
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MeSH Terms
Anti-Arrhythmia Agents / therapeutic use
Atrial Premature Complexes / drug therapy,  genetics*,  ultrasonography
Bradycardia / drug therapy,  genetics*,  ultrasonography
Cause of Death
Fetal Diseases / drug therapy,  genetics*,  ultrasonography
Hypoplastic Left Heart Syndrome / genetics*
Risk Factors
Severity of Illness Index
Tachycardia, Ectopic Atrial / drug therapy,  genetics*,  ultrasonography
Reg. No./Substance:
0/Anti-Arrhythmia Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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