| Familial association of congenital left heart abnormalities and sustained fetal arrhythmia. | |
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MedLine Citation:
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PMID: 10441694 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hypoplastic left heart syndrome (HLHS) is the most common cause of death from heart disease in the first week of life. There are reports about familial concordance by presumed morphogenetic mechanisms of abnormal embryonic blood flow with phenotypes of varying severity. The risk of having a child with a left heart lesion after a previously affected child may be as high as 5% to 12%. We present case reports from four families in which sustained fetal arrhythmia (three ectopic atrial tachycardias and one severe bradycardia due to excessive ectopic atrial beats) was demonstrated. Within these four families a close relative of the mother (a previous child, a brother, or a nephew) had severe left heart abnormality (three with HLHS and one with severe aortic valve stenosis). The association of sustained fetal arrhythmia of ectopic atrial origin and severe left heart abnormalities could be expected to occur by chance in a very low percentage of cases. We conclude that sustained fetal atrial ectopic arrhythmia is a congenital abnormality and should be considered as a risk factor for inherited congenital heart abnormalities. |
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Authors:
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J Hajdú; T Marton; E Tóth-Pál; Z Papp |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Pediatric cardiology Volume: 20 ISSN: 0172-0643 ISO Abbreviation: Pediatr Cardiol Publication Date: 1999 Sep-Oct |
Date Detail:
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Created Date: 1999-09-02 Completed Date: 1999-09-02 Revised Date: 2008-02-20 |
Medline Journal Info:
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Nlm Unique ID: 8003849 Medline TA: Pediatr Cardiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 368-70 Citation Subset: IM |
Affiliation:
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1st Department of Obstetrics and Gynecology, Semmelweis University Medical School, Budapest H-1088, Baross Strasse 27, Hungary. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anti-Arrhythmia Agents / therapeutic use Atrial Premature Complexes / drug therapy, genetics*, ultrasonography Bradycardia / drug therapy, genetics*, ultrasonography Cause of Death Echocardiography Female Fetal Diseases / drug therapy, genetics*, ultrasonography Humans Hypoplastic Left Heart Syndrome / genetics* Pedigree Phenotype Risk Factors Severity of Illness Index Tachycardia, Ectopic Atrial / drug therapy, genetics*, ultrasonography |
| Chemical | |
Reg. No./Substance:
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0/Anti-Arrhythmia Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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