Document Detail


Familial aggregation of intracranial aneurysms in an Inuit patient population in Kalaallit Nunaat (Greenland).
MedLine Citation:
PMID:  12535364     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The incidence of subarachnoid hemorrhage (SAH) and intracranial aneurysm (IA) has been reported to be higher in Greenlandic Inuits than in Caucasian Danes, but the rate of familial aggregation in Inuits is unknown. METHODS: This study retrospectively compared the rate of familial aggregation of SAH and IA (at least one first- or second-degree relative with presumed SAH and/or IA) in 120 Inuit patients from Greenland admitted to the Copenhagen University Hospital in Copenhagen, Denmark, from 1978 to 1998 with a diagnosis of ruptured IA with that in 1,037 Caucasian Danes admitted from 1978 to 1983. RESULTS: Inuit patients had a much higher rate of familial history of SAH (23.1%) and of IA (9.6%) than Danish patients (4.3 and 1.6%, respectively). In both populations, familial SAH was associated with lower age at the time of aneurysm rupture. Danish patients with familial SAH showed a higher rate of middle cerebral artery aneurysms (40 versus 26% in sporadic SAH). In Inuit patients with familial and nonfamilial SAH, 42 and 38% of the aneurysms originated from the middle cerebral artery. The overall rate of multiple aneurysms was highest among Inuits, and in both populations, it was increased in the presence of a positive family history. CONCLUSION: The rate of a positive family history of presumed SAH and IA is high among Inuits who present with SAH compared with Caucasian Danes who present with SAH. This finding, coupled with a higher rate of multiple aneurysms and younger age at presentation, suggests a potential genetic influence among Inuit families.
Authors:
Lars Lindgaard; Vagn Eskesen; Flemming Gjerris; Niels Vidiendal Olsen
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neurosurgery     Volume:  52     ISSN:  0148-396X     ISO Abbreviation:  Neurosurgery     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-01-21     Completed Date:  2003-03-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7802914     Medline TA:  Neurosurgery     Country:  United States    
Other Details:
Languages:  eng     Pagination:  357-62; discussion 362-3     Citation Subset:  IM    
Affiliation:
University Clinic of Neuroanaesthesia, The Neuroscience Center, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark.
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MeSH Terms
Descriptor/Qualifier:
Adult
Age Factors
Aneurysm, Ruptured / epidemiology,  genetics*
Cross-Sectional Studies
European Continental Ancestry Group / genetics
Female
Gene Frequency / genetics
Genetic Predisposition to Disease / genetics
Genetics, Population / statistics & numerical data
Greenland / epidemiology
Humans
Intracranial Aneurysm / epidemiology,  genetics*
Inuits / genetics*
Male
Middle Aged
Pedigree
Retrospective Studies
Sex Factors
Subarachnoid Hemorrhage / epidemiology,  genetics*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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