Document Detail


Familial aggregation in skin flush response to niacin patch among schizophrenic patients and their nonpsychotic relatives.
MedLine Citation:
PMID:  16936284     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Though a reduced flush response to niacin has been found in schizophrenic patients, whether it is a vulnerability indicator to schizophrenia remains little known. We aimed to examine the familial aggregation in niacin flush response among schizophrenic patients and their nonpsychotic relatives. In a sample of 153 schizophrenia probands, 217 parents, 70 siblings, and 94 normal subjects, 3 concentrations (0.001 M, 0.01 M, and 0.1 M) of niacin were applied to the forearm skin and the flush response was rated at 5, 10, and 15 minutes, respectively, with a 4-point scale. Both the heritability for continuous flush scores and the recurrence risk ratios for binary non-flush response in the nonpsychotic relatives of schizophrenic patients were estimated, and ordinal logistic regression analyses of relatives' niacin response on probands' were further conducted to adjust for potential confounders. The greatest heritabilities ranged from 47% (0.01 M at 10 minutes) to 54% (0.1 M at 5 minutes). The risk ratios of 0.01 M at 10 minutes (ranging from 2.60 for using score 1 or less to 5.06 for using score 0 as non-flush) and 5 minutes (1.66 for using score 0 as non-flush) were significantly greater than one. Multiple ordinal logistic regression analyses further revealed that the association between probands and relatives in niacin flush response remained after adjustment for potential confounders, including age, sex, allergy, tobacco smoking, and coffee drinking. These findings provide support for the potential of niacin flush response as a vulnerability indicator to schizophrenia.
Authors:
Sheng-Hsiang Lin; Chih-Min Liu; Shu-Sen Chang; Hai-Gwo Hwu; Shi K Liu; Tzung J Hwang; Ming-Hsien Hsieh; Shi-Chin Guo; Wei J Chen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-08-25
Journal Detail:
Title:  Schizophrenia bulletin     Volume:  33     ISSN:  0586-7614     ISO Abbreviation:  Schizophr Bull     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2006-12-21     Completed Date:  2007-03-19     Revised Date:  2013-06-07    
Medline Journal Info:
Nlm Unique ID:  0236760     Medline TA:  Schizophr Bull     Country:  United States    
Other Details:
Languages:  eng     Pagination:  174-82     Citation Subset:  IM    
Affiliation:
Institute of Epidemiology, College of Public Health, National Taiwan University, 17 Xuzhou Road, Taipei 100, Taiwan.
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MeSH Terms
Descriptor/Qualifier:
Administration, Cutaneous
Adult
Aged
Dose-Response Relationship, Drug
Female
Flushing / diagnosis,  genetics*
Genetic Predisposition to Disease / genetics*
Genetic Variation / genetics
Humans
Logistic Models
Male
Middle Aged
Niacin / administration & dosage,  diagnostic use*
Phenotype
Risk Assessment
Schizophrenia / diagnosis,  genetics*
Chemical
Reg. No./Substance:
59-67-6/Niacin
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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