Document Detail


Familial aggregation of hypertension treatment and control in the Genetic Epidemiology Network of Arteriopathy (GENOA) study.
MedLine Citation:
PMID:  15121494     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To assess if the treatment and control of hypertension aggregates in families. METHODS: The Genetic Epidemiology Network of Arteriopathy (GENOA) study enrolled sibships between 1997 and 1999, including 1329 hypertensive non-Hispanic blacks (1057 sibling pairs) from Jackson, Mississippi, 1133 hypertensive non-Hispanic whites (859 sibling pairs) from Rochester, Minnesota, and 752 hypertensive Hispanic whites (627 sibling pairs) from Starr County, Texas. Hypertension awareness and drug treatment were ascertained at examination; control was defined by blood pressure levels <140/90 mm Hg. As a measure of familial aggregation, odds ratios were calculated to assess concordance between sibling pairs in the treatment and control of hypertension. RESULTS: Overall, 90.5% of subjects were aware of their hypertension; 90.6% of those who were aware were treated with antihypertensive drugs and 56.0% of those treated had their hypertension controlled. There was statistically significant sib-sib concordance in the treatment of hypertension (odds ratio [OR] = 1.61; 95% confidence interval [CI]: 1.25 to 2.47; P = 0.003) and in the control of drug-treated hypertension (OR = 1.51; 95% CI: 1.25 to 1.81; P <0.0001). CONCLUSION: These findings suggest that the treatment and control of hypertension aggregates in families.
Authors:
Paul R Daniels; Sharon L R Kardia; Craig L Hanis; C Andrew Brown; Richard Hutchinson; Eric Boerwinkle; Stephen T Turner;
Related Documents :
17435564 - Blood pressure before and after electroconvulsive therapy in hypertensive and nonhypert...
15119744 - Hypertensive encephalopathy mimicking brainstem tumour in psychiatric patient.
8087174 - Pathogenesis of vascular dementia: the possible role of hypertension.
6107554 - Community programme for control of hypertension in north karelia, finland.
3128124 - Ovine fetal adrenal gland and cardiovascular function.
24828684 - Constitutive relations for pressure-driven stiffening in poroelastic tissues.
Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of medicine     Volume:  116     ISSN:  0002-9343     ISO Abbreviation:  Am. J. Med.     Publication Date:  2004 May 
Date Detail:
Created Date:  2004-05-03     Completed Date:  2004-05-27     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0267200     Medline TA:  Am J Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  676-81     Citation Subset:  AIM; IM    
Affiliation:
Division of Hypertension and Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
African Americans / statistics & numerical data
Antihypertensive Agents / therapeutic use*
European Continental Ancestry Group / statistics & numerical data
Family Health*
Female
Health Knowledge, Attitudes, Practice*
Hispanic Americans / statistics & numerical data
Humans
Hypertension / drug therapy,  ethnology,  prevention & control*
Male
Middle Aged
Minnesota / epidemiology
Mississippi / epidemiology
Odds Ratio
Siblings*
Statistics, Nonparametric
Texas / epidemiology
Grant Support
ID/Acronym/Agency:
HL54457/HL/NHLBI NIH HHS; HL54463/HL/NHLBI NIH HHS; HL54464/HL/NHLBI NIH HHS; HL54481/HL/NHLBI NIH HHS; HL54504/HL/NHLBI NIH HHS; HL54526/HL/NHLBI NIH HHS; HL68737/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Antihypertensive Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  End-of-life care in a voluntary hospitalist model: effects on communication, processes of care, and ...
Next Document:  Exercise-based rehabilitation for patients with coronary heart disease: systematic review and meta-a...