Document Detail


Familial aggregation of hyperemesis gravidarum.
MedLine Citation:
PMID:  20974461     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: This study was undertaken to determine whether there is familial aggregation of hyperemesis gravidarum (HG), making it a disease amenable to genetic study.
STUDY DESIGN: Cases with severe nausea and vomiting in a singleton pregnancy treated with intravenous hydration and unaffected friend controls completed a survey regarding family history.
RESULTS: Sisters of women with HG have a significantly increased risk of having HG themselves (odds ratio, 17.3; P = .005). Cases have a significantly increased risk of having a mother with severe nausea and vomiting; 33% of cases reported an affected mother compared to 7.7% of controls (P < .0001). Cases reported a similar frequency of affected second-degree maternal and paternal relatives (18% maternal lineage, 23% paternal lineage).
CONCLUSION: There is familial aggregation of HG. This study provides strong evidence for a genetic component to HG. Identification of the predisposing gene(s) may determine the cause of this poorly understood disease of pregnancy.
Authors:
Yafeng Zhang; Rita M Cantor; Kimber MacGibbon; Roberto Romero; Thomas M Goodwin; Patrick M Mullin; Marlena S Fejzo
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Intramural     Date:  2010-10-25
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  204     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-03-07     Completed Date:  2011-06-29     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  230.e1-7     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2011 Mosby, Inc. All rights reserved.
Affiliation:
Department of Human Genetics, David Geffen School of Medicine, University of California-Los Angeles, CA 90095, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Family
Female
Genetic Predisposition to Disease
Humans
Hyperemesis Gravidarum / etiology,  genetics*
Nausea
Pregnancy
Vomiting
Grant Support
ID/Acronym/Agency:
N01 HD023342/HD/NICHD NIH HHS
Comments/Corrections

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