Document Detail

Familial aggregation and heritability of electrocardiographic intervals and heart rate in a rural Chinese population.
MedLine Citation:
PMID:  19419399     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Estimates of the genetic influences on electrocardiographic (ECG) parameters are inconsistent in previous reports, and no such studies have been performed in China. So we estimated genetic contributions to PR and QRS intervals and the rate-adjusted QT interval (Bazett's QTc) in a Chinese rural population. METHODS: A total of 2909 subjects from 847 families were enrolled in the current study. Genetic contributions to ECG parameters were estimated in two ways: correlation coefficients among family members (father-mother, parent-offspring, first sibling-other sibling) and the heritability of each of the ECG parameters. RESULTS: Our results showed significant correlations among family members on theses parameters: the correlation coefficients for PR interval, QRS duration, QTc interval, and HR, between parent-sibling, and sibling-sibling were 0.17 and 0.13, 0.18 and 0.23, 0.22 and 0.28, 0.19 and 0.18, respectively. The heritability for PR interval, QRS duration, QTc interval, and HR were estimated as 0.34, 0.43, 0.40, and 0.34, respectively. CONCLUSION: Genetic factors, together with the environmental and other cofactors contribute no more than 60% to the variance of the ECG intervals, supporting the concept that multiple factors, including gene-gene and gene-environment interactions could influence ECG interval phenotypes, and genetic factors play a major role.
Jianping Li; Yong Huo; Yan Zhang; Zhian Fang; Jianhua Yang; Tonghua Zang; Xiping Xu; Xin Xu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc     Volume:  14     ISSN:  1542-474X     ISO Abbreviation:  Ann Noninvasive Electrocardiol     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-05-07     Completed Date:  2009-08-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9607443     Medline TA:  Ann Noninvasive Electrocardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  147-52     Citation Subset:  IM    
Peking University First Hospital, Department of Cardiology, Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, 8 Xishiku St., Xicheng District, Beijing, China.
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MeSH Terms
Analysis of Variance
Child, Preschool
China / epidemiology
Electrocardiography / methods*
Genetic Predisposition to Disease / epidemiology*,  genetics*
Heart Rate / genetics*
Long QT Syndrome / epidemiology*,  genetics
Middle Aged
Reference Values
Rural Population / statistics & numerical data
Sex Distribution
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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