Document Detail


Familial aggregation of food allergy and sensitization to food allergens: a family-based study.
MedLine Citation:
PMID:  19016802     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The increasing prevalence of food allergy (FA) is a growing clinical and public health problem. The contribution of genetic factors to FA remains largely unknown.
OBJECTIVE: This study examined the pattern of familial aggregation and the degree to which genetic factors contribute to FA and sensitization to food allergens.
METHODS: This study included 581 nuclear families (2,004 subjects) as part of an ongoing FA study in Chicago, IL, USA. FA was defined by a set of criteria including timing, clinical symptoms obtained via standardized questionnaire interview and corroborative specific IgE cut-offs for > or =95% positive predictive value (PPV) for food allergens measured by Phadia ImmunoCAP. Familial aggregation of FA as well as sensitization to food allergens was examined using generalized estimating equation (GEE) models, with adjustment for important covariates including age, gender, ethnicity and birth order. Heritability was estimated for food-specific IgE measurements.
RESULTS: FA in the index child was a significant and independent predictor of FA in other siblings (OR=2.6, 95% CI: 1.2-5.6, P=0.01). There were significant and positive associations among family members (father-offspring, mother-offspring, index-other siblings) for total IgE and specific IgE to all the nine major food allergens tested in this sample (sesame, peanut, wheat, milk, egg white, soy, walnut, shrimp and cod fish). The estimated heritability of food-specific IgE ranged from 0.15 to 0.35 and was statistically significant for all the nine tested food allergens.
CONCLUSION: This family-based study demonstrates strong familial aggregation of FA and sensitization to food allergens, especially, among siblings. The heritability estimates indicate that food-specific IgE is likely influenced by both genetic and environmental factors. Together, this study provides strong evidence that both host genetic susceptibility and environmental factors determine the complex trait of IgE-mediated FA.
Authors:
H-J Tsai; R Kumar; J Pongracic; X Liu; R Story; Y Yu; D Caruso; J Costello; A Schroeder; Y Fang; H Demirtas; K E Meyer; M R G O'Gorman; X Wang
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2008-10-30
Journal Detail:
Title:  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology     Volume:  39     ISSN:  1365-2222     ISO Abbreviation:  Clin. Exp. Allergy     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-01-08     Completed Date:  2009-02-13     Revised Date:  2014-09-21    
Medline Journal Info:
Nlm Unique ID:  8906443     Medline TA:  Clin Exp Allergy     Country:  England    
Other Details:
Languages:  eng     Pagination:  101-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Allergens / administration & dosage,  adverse effects*,  immunology
Animals
Cats
Child
Child, Preschool
Dogs
Family*
Female
Food Hypersensitivity* / diagnosis,  epidemiology,  genetics,  immunology
Genetic Predisposition to Disease*
Humans
Immunoglobulin E / blood*
Infant
Infant, Newborn
Interviews as Topic
Male
Prevalence
Questionnaires
Young Adult
Grant Support
ID/Acronym/Agency:
M01 RR-00048/RR/NCRR NIH HHS; R21 AI079872/AI/NIAID NIH HHS; R21 AI079872-01/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Allergens; 37341-29-0/Immunoglobulin E
Comments/Corrections

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