Document Detail


Familial aggregation of dementia with Lewy bodies.
MedLine Citation:
PMID:  21220678     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Familial aggregation of dementia with Lewy bodies (DLB) remains unclear.
OBJECTIVES: To determine the degree of family aggregation of DLB by comparing DLB risk between siblings of probands with clinically diagnosed DLB and siblings of probands with clinically diagnosed Alzheimer disease in a cohort of Caribbean Hispanic families and to explore the degree of aggregation of specific clinical manifestations (ie, cognitive fluctuations, visual hallucinations, and parkinsonism) in DLB.
DESIGN: Familial cohort study.
SETTING: Academic research.
PATIENTS: We separately compared risks of possible DLB, probable DLB, and clinical core features of DLB (cognitive fluctuations, visual hallucinations, and parkinsonism) between siblings of probands with clinically diagnosed DLB (n = 344) and siblings of probands with clinically diagnosed Alzheimer disease (n = 280) in 214 Caribbean Hispanic families with extended neurologic and neuropsychological assessment.
MAIN OUTCOME MEASURES: We applied general estimating equations to adjust for clustering within families. In these models, age and proband disease status were independent variables, and disease status of siblings was the measure of disease risk and the dependent variable.
RESULTS: Compared with siblings of probands having clinically diagnosed Alzheimer disease, siblings of probands having clinically diagnosed DLB had higher risks of probable DLB (odds ratio [OR], 2.29; 95% confidence interval [CI], 1.04-5.04) and visual hallucinations (2.32; 1.16-4.64). They also had increased risks of possible DLB (OR, 1.51; 95% CI, 0.97-2.34) and cognitive fluctuations (1.55; 0.95-2.53).
CONCLUSIONS: Dementia with Lewy bodies and core features of DLB aggregate in families. Compared with siblings of probands having clinically diagnosed AD, siblings of probands having clinically diagnosed DLB are at increased risks of DLB and visual hallucinations. These findings are an important step in elucidating the genetic risk factors underlying DLB and in delineating DLB from other neurodegenerative diseases, such as Alzheimer disease.
Authors:
Angela Nervi; Christiane Reitz; Ming-Xin Tang; Vincent Santana; Angel Piriz; Dolly Reyes; Rafael Lantigua; Martin Medrano; Ivonne Z Jiménez-Velázquez; Joseph H Lee; Richard Mayeux
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of neurology     Volume:  68     ISSN:  1538-3687     ISO Abbreviation:  Arch. Neurol.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-11     Completed Date:  2011-02-14     Revised Date:  2013-07-02    
Medline Journal Info:
Nlm Unique ID:  0372436     Medline TA:  Arch Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  90-3     Citation Subset:  AIM; IM    
Affiliation:
Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Alzheimer Disease / genetics,  psychology
Caribbean Region
Cohort Studies
Female
Follow-Up Studies
Hispanic Americans / genetics
Humans
Lewy Bodies / genetics*
Lewy Body Disease / genetics*,  psychology
Male
Middle Aged
Neuropsychological Tests
Grant Support
ID/Acronym/Agency:
2P30AG/15294-06/AG/NIA NIH HHS; K23AG034550/AG/NIA NIH HHS; P01 AG007232-20/AG/NIA NIH HHS; P01-AG07232/AG/NIA NIH HHS; R37 AG015473-14/AG/NIA NIH HHS; R37-AG15473/AG/NIA NIH HHS
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