Document Detail

Familial adenomatous polyposis: should patients undergo surveillance of the upper gastrointestinal tract?
MedLine Citation:
PMID:  7601038     Owner:  NLM     Status:  MEDLINE    
Upper gastrointestinal (UGI) endoscopy was performed in 35 asymptomatic patients with familial adenomatous polyposis (FAP) to assess the prevalence of gastric and duodenal polyps and to demonstrate efficacy of endoscopic surveillance in patients with FAP. UGI polyps were found in 25 (71%) of 35 polyposis patients. Among these, gastric fundic gland polyps were involved in seven patients, and UGI adenomas in 18 patients; there were nine gastric adenomas and 14 duodenal adenomas, including six cases of duodenal cancer. UGI polyps were found in 13 of 15 patients with extracolonic manifestations (87%), but in only 12 of 20 patients (60%) without. The median follow-up interval was 8.7 years in growing duodenal adenomas, but 3.5 years in adenomas without changes in size and number. It was concluded that surveillance gastroduodenoscopy every 3-5 years might be enough to treat duodenal adenomas by endoscopic mucosal resection.
T Sawada; T Muto
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Endoscopy     Volume:  27     ISSN:  0013-726X     ISO Abbreviation:  Endoscopy     Publication Date:  1995 Jan 
Date Detail:
Created Date:  1995-08-10     Completed Date:  1995-08-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0215166     Medline TA:  Endoscopy     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  6-11     Citation Subset:  IM    
First Department of Surgery, University of Tokyo, Japan.
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MeSH Terms
Adenomatous Polyposis Coli / diagnosis*,  epidemiology,  pathology,  therapy
Diagnosis, Differential
Endoscopy, Gastrointestinal
Middle Aged
Retrospective Studies
Risk Factors

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