Document Detail

Familial abdominal aortic aneurysm: prevalence and implications for screening.
MedLine Citation:
PMID:  8270076     Owner:  NLM     Status:  MEDLINE    
The high prevalence of abdominal aortic aneurysm (AAA) in men over the age of 65 has led to the establishment of ultrasound screening programmes for this group. The apparent familial tendency towards AAA formation suggests that relatives of aneurysm patients may form another subpopulation in whom screening is appropriate. The first degree relatives of 100 consecutive aneurysm patients were identified. Of 110 relatives over 50 years of age, two were known to have had AAA and ultrasound scans were performed on 74, providing information on aortic size for 76 relatives (69%). No further aortic aneurysms (antero-posterior diameter > or = 4.0 cm) were found on scanning. However, nine relatives were demonstrated to have aortic dilatation (2.5-3.9 cm). Aortic dilatation was observed in 21% of male first degree relatives over 50 years of age, affecting 27% of sons and 17% of brothers. Only 4% of the sisters and none of the daughters were found to have aortic dilatation. The prevalence of aortic enlargement seems to be sufficiently high amongst male first degree relatives of AAA patients over 50 years of age to justify aortic screening.
D C Adams; B R Tulloh; S W Galloway; E Shaw; A J Tulloh; K R Poskitt
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of vascular surgery     Volume:  7     ISSN:  0950-821X     ISO Abbreviation:  Eur J Vasc Surg     Publication Date:  1993 Nov 
Date Detail:
Created Date:  1994-02-03     Completed Date:  1994-02-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8709440     Medline TA:  Eur J Vasc Surg     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  709-12     Citation Subset:  IM    
Department of Vascular Surgery, Cheltenham General Hospital, Gloucestershire, U.K.
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MeSH Terms
Aged, 80 and over
Aortic Aneurysm, Abdominal / epidemiology,  genetics*,  prevention & control
England / epidemiology
Feasibility Studies
Mass Screening
Middle Aged
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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