Document Detail


Familial occurrence of peripartum cardiomyopathy presages a genetic rather than an environmental cause.
MedLine Citation:
PMID:  20844994     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Peripartum cardiomyopathy (PPCM) is an uncommon form of left ventricular dysfunction associated with pregnancy and triggered by a number of obstetric factors including pre-eclampsia, plural gestations and multiparity. PPCM is the most frequent cause of pregnancy-related maternal death. Although the clinical outcome of PPCM has been determined, its patho-etiology has not been elucidated. Two recent studies have demonstrated for the first time in a small proportion of patients, convincing evidence of a genetic predisposition for PPCM, activated by modifier genes responding to biochemical and hemodynamic signals during mid to late pregnancy.
Authors:
Martin St John Sutton
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Current heart failure reports     Volume:  7     ISSN:  1546-9549     ISO Abbreviation:  Curr Heart Fail Rep     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101196487     Medline TA:  Curr Heart Fail Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  153-5     Citation Subset:  IM    
Affiliation:
Division of Cardiovascular Medicine, University of Pennsylvania Medical Center, 3400 Spruce Street, Philadelphia, PA 19104, USA. suttonm@mail.med.upenn.edu
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