| Familial occurrence of peripartum cardiomyopathy presages a genetic rather than an environmental cause. | |
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MedLine Citation:
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PMID: 20844994 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Peripartum cardiomyopathy (PPCM) is an uncommon form of left ventricular dysfunction associated with pregnancy and triggered by a number of obstetric factors including pre-eclampsia, plural gestations and multiparity. PPCM is the most frequent cause of pregnancy-related maternal death. Although the clinical outcome of PPCM has been determined, its patho-etiology has not been elucidated. Two recent studies have demonstrated for the first time in a small proportion of patients, convincing evidence of a genetic predisposition for PPCM, activated by modifier genes responding to biochemical and hemodynamic signals during mid to late pregnancy. |
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Authors:
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Martin St John Sutton |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Current heart failure reports Volume: 7 ISSN: 1546-9549 ISO Abbreviation: Curr Heart Fail Rep Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-03 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101196487 Medline TA: Curr Heart Fail Rep Country: United States |
Other Details:
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Languages: eng Pagination: 153-5 Citation Subset: IM |
Affiliation:
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Division of Cardiovascular Medicine, University of Pennsylvania Medical Center, 3400 Spruce Street, Philadelphia, PA 19104, USA. suttonm@mail.med.upenn.edu |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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