Document Detail

Familial Mediterranean fever (FMF) and multiple sclerosis: an association study in one of the world's largest FMF cohorts.
MedLine Citation:
PMID:  21299735     Owner:  NLM     Status:  Publisher    
Background and purpose:  To describe and characterize the association between familial Mediterranean fever (FMF) and multiple sclerosis (MS). Methods:  The patient registry of The National Center for FMF was screened for the coexistence of FMF and MS. Tel-Hashomer criteria were used for the diagnosis of FMF, and FMF severity was evaluated, using the simplified FMF severity scale. McDonald criteria were used for the diagnosis of MS, and neurologic disability was measured using the expanded disability status scale (EDSS). Results:  We identified nine patients, affected with both FMF and MS. The onset of the FMF averaged 15.6 (3-37) years. Most patients suffered from abdominal and joint attacks, and 50% of the patients sustained a moderate to severe FMF. The onset of the MS was at an average age of 31.6 (17-50) years. Neurologic manifestations varied individually, without a dominant deficit, and the course was in a relapsing-remitting pattern in most. The median EDSS was in general of low score (3.0), apart from the patients who were homozygous for the M694V mutation, in whom the MS was more severe. Based on our case series, the frequency of MS in our FMF population is 0.075%, twice higher the expected rate in the general population (P = 0.0057). Conclusions:  Multiple sclerosis is more common in FMF than in the general Israeli population. Homozygosity for the M694V MEFV mutation may aggravate the phenotype of MS and predispose FMF patients to develop MS.
G Yahalom; S Kivity; M Lidar; A Vaknin-Dembinsky; D Karussis; S Flechter; E Ben-Chetrit; A Livneh
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-2-8
Journal Detail:
Title:  European journal of neurology : the official journal of the European Federation of Neurological Societies     Volume:  -     ISSN:  1468-1331     ISO Abbreviation:  -     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-2-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9506311     Medline TA:  Eur J Neurol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 The Author(s). European Journal of Neurology © 2011 EFNS.
 Department of Neurology, the Chaim Sheba Medical Center, Tel-Hashomer  The unit of Rheumatology, Department of Medicine A+C, the Chaim Sheba Medical Center, Tel-Hashomer  Department of Medicine F, the Chaim Sheba Medical Center, Tel-Hashomer  Department of Neurology and Agnes-Ginges Center for Neurogenetics, Hadassah-Hebrew University Hospital, Ein-Kerem, Jerusalem  Department of Neurology, Asaf Harofe Medical Center, Zriffin  Department of Internal Medicine A, Hadassah-Hebrew University Medical Center, Ein Kerem, Jerusalem  Tel Aviv University, Tel-Aviv  Hadassah-Hebrew University Medical Center, Ein Kerem, Jerusalem, Israel.
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